Researcher in Systems Medicine

We are looking for a researcher in systems medicine for a permanent position at the School of Medical Sciences.

Subject area
The primary research area is systems medicine, with emphasis on identification and validation of disease biomarkers of non-alcoholic fatty liver disease (NAFLD) based on metabolomics and other relevant genetic and clinical data. Research will also involve setting up in vitro models (hepatocyte cell lines, liver and possibly other organoids) for functional validation. The position will also support other projects and collaborations in the Systems medicine team, by contributing to mining of multi-modal data and analyses of biological networks in health and disease. 

Background
The researcher will contribute to IMI project LITMUS - Liver Investigation: Testing Marker Utility in Steatohepatitis, as well as to other related projects, where molecular diagnostic tools are being developed to diagnose and monitor NAFLD.

The research focus is on applications of multivariate and network/pathway modelling approaches to identify the key pathways and markers associated with progression of NAFLD – based on multiomics data including metabolomics (plasma and human liver biopsies), RNAseq (liver biopsies) and metagenomics (gut microbiota) from multiple human cohort studies. The aim is also to translate the research findings into the diagnostic application, and to functionally characterize the underlying pathways using model systems. The researcher will also be involved in planning of in vitro functional validation studies at Örebro University and contribute to analysis and interpretation of metabolomics and other ‘omics’ and clinical data in Systems Medicine team at Örebro University.

Duties and responsibilities
A researcher shall spend their working hours mainly on research. The appointment may also include teaching, when there is a need within the organisation, to facilitate the researcher to acquire qualifications for a teaching appointment at the University. The share of teaching may not exceed a 20 per cent of a full-time post.

Qualifications
Those qualified for the appointment as a researcher are applicants who have obtained a doctoral degree or have a degree from abroad deemed to correspond to a doctoral degree.

Assessment criteria
Documented knowledge and experience in biochemistry, biostatistics and statistical learning, involving analysis of biological high-throughput data, as well as experience in cell and molecular biology (in vitro models of disease) is a requirement. Experience with medical applications of metabolomics, modelling of biological networks, stem cell biology, and metabolic research in general are merits. The applicant should be an expert in the R statistical language.

The successful candidate should be creative, have the ability to both co-operate and independently work with research questions. Proficiency in written and spoken English is a requirement.

A general basis for assessment is that the applicant is able to demonstrate the personal qualities required to successfully perform the duties and responsibilities at hand; that they are able to cooperate with other members of staff; and contribute to the development of university operations.

Information
This is a permanent full-time position. At Örebro University, salary depends on the successful candidate’s qualifications and experience.

For more information about the position, contact Matej Oresic +46 76 9464459, email: matej.oresic@oru.se, or +46 19 301307, email: wessam.melik@oru.se.

At Örebro University, we expect each member of staff to be open to development and change; take responsibility for their work and performance; demonstrate a keen interest in collaboration and contribute to development; as well as to show respect for others by adopting a constructive and professional approach.

Örebro University actively pursues equal opportunities and gender equality as well as a work environment characterized by openness, trust and respect. We value the qualities that diversity adds to our operations.

Application
The application is made online. Click the button “Apply” to begin the application procedure.

For the application to be complete, the following electronic documents must be included:


• Covering letter, outlining how you believe you can contribute to the continued development of Örebro University
• CV with a relevant description of your overall qualifications and experience
• Account of [research/artistic] qualifications and experience
• Copies of relevant course/degree certificates and references verifying eligibility and criteria met

Only documents written in Swedish, English, Norwegian and Danish can be reviewed.
More information for applicants will be found at out career site:  https://www.oru.se/english/working-at-orebro-university/jobs-and-vacancies/applicants-and-external-experts/

The application deadline is 2022-01-26. We look forward to receiving your application!

We decline any contact with advertisers or recruitment agencies in the recruitment process.

As directed by the National Archives of Sweden (Riksarkivet), we are required to deposit one file copy of the application documents, excluding publications, for a period of two years after the appointment decision has gained legal force.