Scientist, Bioscience In Vivo - immunology

Are you an experienced in vivo Scientist ready to apply your skills in a diverse and dynamic company? If you can envision providing extensive hands on in vivo expertise in a role that can impact patients' lives - join us now!


We are now looking to recruit an In Vivo Scientist to support our Bioscience In Vivo Department, within Early Respiratory & Immunology in planning and executing in vivo studies to contribute to the identification of new targets, biomarkers and the progression of drug discovery projects. The role is located at our vibrant R&D site located in Gothenburg, Sweden.


At AstraZeneca, we believe in the potential of our people and you will develop beyond what you thought possible. We make the most of your skills and passion by actively supporting you to see what you can achieve no matter where you start with us.



Respiratory & Immunology is one of AstraZeneca's main therapy areas. From a research perspective we work to understand, treat, modify and ultimately cure respiratory and autoimmune diseases with an emphasis on inflammatory bowel disease (IBD), systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), atopic dermatitis (AD).



The successful candidate will join a highly motivated team within the In vivo Bioscience section. The wider team works closely together with other departments focusing on Target Translational Science, Bioscience In vitro assays and Drug Metabolism/Pharmacokinetics, to support discovery projects and new exciting research.



What you'll do
As a Scientist you will be a vital member of the in vivo community and will contribute to the development and characterization of pre-clinical models of autoimmune diseases to discover novel therapeutics. This is a lab-based role where, under the supervision of the team leader and help from colleagues, you will plan and execute experiments, with the responsibility to coordinate, perform and analyze in vivo studies. You will perform ex vivo assays to analyze the in vivo studies and contribute to the interpretation and the communication of the results to provide inputs on next steps.

We are looking for a strong team player with high degree of flexibility and collaborative skills to help projects reaching the next milestone according to timelines.


Essential for the role
* B.Sc. or M.Sc. degree in relevant subjects or equivalent level of understanding developed through experience in academia or drug discovery settings
* Several years of hands on experience with rodents including live animal handling, drug administration through different routes, blood and organ sampling and processing (spleen, lymph nodes, intestine)
* Ability to organize, execute and interpret the results from in vivo studies according to study plans in agreement with the team leader or other colleagues
* Experience with in vitro methods to analyze ex vivo samples generated from in vivo studies
* Experience of maintaining the highest standards of welfare and ethical compliance and ensuring the integrity of the generated data. Familiar with using Good Statistical Practice in animal research and applying the 3R's (reduction, refinement and replacement) across the full range of studies
* Excellent English written and oral communication skills, including presentation skills
* Strong organization skills and wiliness to incorporate the views of others in your communication and collaboration


Desirable for the role
* Valid education required for compliance to work with live animals in Sweden
* Good written and oral communication skills in Swedish and experience in writing ethical applications for animal work in Sweden
* Understanding of autoimmune and autoinflammatory diseases with a specific focus on gut immunology
* Experience with animal models of inflammatory bowel disease (IBD) and in vivo PK/PD relationships
* Experience with flow cytometry, ELISA, western blot and/or qRT-PCR


Why AstraZeneca?
AstraZeneca is a global, innovation-driven BioPharmaceutical business that focuses on the discovery, development and commercialisation of prescription medicines for some of the world's most serious disease. But we're more than one of the world's leading pharmaceutical companies.



About AstraZeneca Gothenburg Site
Our stunning site in Gothenburg is one of AstraZeneca's three strategic science centers. The site is home to over 2,500 employees, from 50 different nationalities. Gothenburg includes the complete range of functions, and as such offers plenty of development opportunities for a wide range of professionals. Our science teams in Gothenburg collaborate with academic and industry partners in Sweden and globally. And the site itself has been designed with collaboration in mind. From the Coffee Lab to exercise areas, we've built a series of environments where innovation can happen.

So, what's next!
Are you already imagining yourself joining our team? Good, because we can't wait to hear from you. Welcome with your application no later than November 28, 2022.