Senior Bioanalytical & Biotransformation Scientist

Would you like to apply your expertise in LCMS Bioanalysis in a company that follows the science and turns ideas into life changing medicines? Then AstraZeneca might be the right place for you!

We are now recruiting a highly motivated Senior Bioanalytical & Biotransformation Scientist to join the Drug Metabolism and Pharmacokinetics (DMPK) department within the Early Respiratory and Immunology (Early R&I) therapeutic area.

At AstraZeneca Respiratory & Immunology, we're proud to have an outstanding workplace culture that encourages innovation and teamwork. Here, employees are empowered to express diverse perspectives - and are made to feel valued, energized and rewarded for their ideas and creativity.

You will be part of the In Vitro and In Vivo Science team where in vivo and in vitro studies are performed and subsequent bioanalysis of drugs, drug metabolites and biomarkers using state of the art LCMS instruments. The position is placed at AstraZeneca's vibrant R&D site in Gothenburg, Sweden.



What you'll do

As a Senior Bioanalytical & Biotransformation Scientist, you will be responsible for delivering quality in vitro and in vivo bioanalytical data of drugs to support Pharmacokinetics and Pharmacodynamics (PKPD) work in projects from target selection to life cycle management (LCM). The data produced is mainly aimed to provide insight in quantitative pharmacology as well as in right tissue and right exposure. The samples include different tissues and a variety of biological fluids as well as sub-cellular fractions. In addition to the quantitative analyses, the role also includes characterization and structure elucidation of drug metabolites in biological samples. With your solid hands-on LC-MSMS analysis experience, you are expected to develop and implement novel approaches and provide significant input to drug project decision making.

This laboratory based scientific role includes developing methods to enable delivery of the necessary quality of data and scientific input aligned with drug project needs. The role requires interactive and effective communication to provide clear data and guidance to project representatives, and contribute to the overall team delivery. This role requires making judgements about bioanalytical input, developing innovative solutions and applying a cross-functional and industry understanding. You will contribute to the discovery of new life changing medicines for patients and demonstrate what science can do.



Essential for the role

*

Background in analytical chemistry, medicinal chemistry, biomedicine or equivalent with at least five years' experience relevant to the position
*

In-depth experience of quantitative LC-MSMS including hands-on competence of analysing different kind of molecules
*

Experience of characterization and structure elucidation of drug metabolites in biological samples with high resolution MS Experience
*

Technical skills to operate, perform regular maintenance and elementary trouble shooting of LC-MSMS instruments
*

Excellent hands-on skills of sample preparation of biofluids for quantification of drugs and endogenous molecules, method development included
*

Track record of performing state-of-the-art bioanalytical analysis and delivery of data to drug discovery and development projects
*

Good organic chemistry knowledge
*

Excellent communication and interpersonal skills
*

Excellent English, both verbal and written
*

Ability to engage and collaborate across boundaries with a problem-solving attitude and focus on delivery



Desirable for the role

*

Experiences of metabolite identification of oligonucleotides and/or peptides



So what´s next?

We would like to know more about you. If you are interested to know more about us, apply now!

Interviews are ongoing, so please don't hesitate with your application, no later than 22 June, 2021



About AstraZeneca Gothenburg

Our stunning campus in Gothenburg is one of AstraZeneca's three strategic science centers. The site is home to over 2,500 employees, from 50 different nationalities. Gothenburg includes the complete range of functions, and as such offers plenty of development opportunities for a wide range of professionals. And the site itself has been designed with collaboration in mind. From the Coffee Lab to exercise areas, we've created a series of environments where innovation can happen.



Additional information

Our Gothenburg site: https://www.astrazeneca.com/our-science/gothenburg.html

Culture and atmosphere of the Gothenburg site: https://www.linkedin.com/feed/update/urn:li:activity:6496327311678410752/

Life in Gothenburg and Sweden: https://www.movetogothenburg.com/