Senior Bioanalytical Scientist

Are you an experienced Bioanalytical scientist with expertise in mass spectrometry? Would you like to apply your expertise in a company that is accelerating innovative science and turn ideas into life changing medicines? Join us to discover future treatment of Cardiovascular, Renal and Metabolic diseases!

At AstraZeneca, you will be empowered to be innovative and creative where difference is valued. We thrive in a place where the brightest and most curious minds seamlessly come together in our inclusive environment. We are committed to the development of next generation innovative medicines and are expanding our cross-functional oligonucleotide capability for the treatment of diseases across therapy areas.

We are now recruiting a Senior Bioanalytical Scientist, to join the Drug Metabolism and Pharmacokinetics (DMPK) department within the Early Cardiovascular, Renal and Metabolism therapeutic area (CVRM).

Early CVRM is one of the three main therapeutic research areas within AstraZeneca which deliver candidate drugs into clinical development. Early CVRM DMPK is based in AstraZeneca's world-class vibrant R&D center, located in Gothenburg, Sweden. DMPK interacts with other functions in supporting CVRM projects along the value chain, from target selection all the way to launch and life cycle management.

The DMPK bioanalysis team delivers fundamental understanding of drug disposition, which includes responsibility for bioanalysis of drug candidates in biological samples generated in non-clinical studies. The data generated is mainly aimed to provide insight to quantitative pharmacology as well as right tissue and right exposure aspects, including the fate of drug substances and metabolites. This role will expand our capability regarding bioanalysis of new modality drugs with focus on oligonucleotides, and stretching to other drug modalities, e.g. peptides, PROTACs, or small molecules and drug conjugates. You will have the opportunity to contribute to the discovery of new life changing medicines for patients and demonstrate and witness what science can do.

We continually push the boundaries of science to deliver medicines that treat diseases across our main therapy areas. Through our integration with Alexion, this now includes expanding the limits of scientific research to better understand rare diseases and to discover new life-changing treatments for them.

What you'll do

This is a lab-based role, where you will act as an expert in your area, providing proficient scientific advice on bioanalysisis of oligonucleotides and other drug modalities.

You will be responsible for analysing drug candidates and their metabolites in various in-vitro and in-vivo samples to support PKPD (Pharmacokinetics and Pharmacodynamics) work in projects from target selection to LCM (life cycle management). Responsibilities include:

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Identify innovative approaches and technologies that would improve our ability to support projects, with the vital quality and scientific input aligned with drug project needs.
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Make judgements about bioanalytical input, develop innovative solutions and apply inter-disciplinary and industry understanding.
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Write manuscripts and publish research together with external/internal collaborators

Essential for the role

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PhD in a relevant field or MSc with equivalent experience.
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Hands-on bioanalysis and LC-MS experience.
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Track record of delivering innovative bioanalysis data to projects in discovery and/or development setting
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Experience in development and application of quantitative bioanalytical methods for oligonucleotides and peptides, experience from other drug modalities is a plus
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Excellent oral and written communication skills in English.

Desirable for the role

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Experience with other analytical technologies and automation
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Experience with HRMS
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Basic understanding of DMPK
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Understanding of the overall drug discovery and development process.

So, what's next?

Are you already imagining yourself joining our team? Good, because we can't wait to hear from you!

For more information about the position please contact hiring manager Mikko Hölttä, Mikko.Holtta@astrazeneca.com. Welcome with your application no later than February 28, 2022.

Where can I find out more?

Our Gothenburg site: https://www.astrazeneca.com/our-science/gothenburg.html

Global Gothenburg: https://www.astrazeneca.se/om-oss/verksamheten-i-sverige/goteborg/relocate-to-gothenburg.html

Life in Gothenburg: https://www.movetogothenburg.com/

Why AstraZeneca?

Our Gothenburg site is one of AstraZeneca's three strategic R&D centers. With more than 2,400 employees from over than 50 countries, our vibrant Gothenburg site is a truly inspiring place to work. Here, the history and future of scientific breakthrough come together. We believe that the diversity of our people is crucial to bringing new discoveries to life.

You will be offered a competitive salary and excellent benefits, such as extra paid Holiday, Private Medical Benefits, On-site exercise and much, much more.