Senior Bioinformatician for Oligonucleotide Therapeutics

Are you a quantitatively-minded scientist looking to apply bioinformatics and machine learning to design oligonucleotides for therapeutic use? Do you wish to join a growing team where you will have the possibility to further exploit our drug discovery platforms? If yes, we have the position for you at AstraZeneca in Gothenburg!

We are currently looking for a Senior Bioinformatician for Oligonucleotide Therapeutics to join us at AstraZeneca in Gothenburg, Sweden. In this position you'll be a part of the Data Sciences and Quantitative Biology team that works as part of the Discovery Sciences organisation, within BioPharma R&D.

The Data Sciences and Quantitative Biology team is a multi-disciplinary team of data scientists with the purpose of providing quantitative insights to biology. We do so by improving the biological understanding of the target and its engagement. Including supporting the identification of molecular mechanisms of action and building a platform for oligonucleotide design. Providing image and data analysis solutions to high dimensional datasets - and by enhancing AstraZeneca's ability to prioritize target selection and projects based on probability of technical success.

You will also be part of our cross-functional Oligonucleotide Therapeutics group. AstraZeneca R&D have been curious about oligonucleotides as a new modality since 2012 and our scientific interest has grown. Therefore, we are now poised to leverage on the wealth of expertise from across our R&D units and through a new matrix organisation to deliver a proprietary Oligonucleotide Therapeutics Platform in-house. We offer a highly rewarding scientific environment along with an inclusive, dynamic and team focused atmosphere - with a goal to design and develop the oligonucleotide therapeutics of the future.

What you'll do:
As Senior Bioinformatician for Oligonucleotide therapeutics, you'll be using bioinformatics and machine learning and collaborate with oligonucleotide drug discovery projects to identify and deliver oligonucleotide sequence designs. Be responsible for developing or internalizing appropriate algorithms, techniques and datasets to advance our ability to rapidly discover oligonucleotide candidate drugs.

You will also enhance our data analysis capabilities on complex, high-dimensional -omics data to identify biologically induced effects of oligonucleotides. As well as contributing to and leading local and global projects for NGS applied in oligonucleotide projects and ensuring that results are scientifically robust and documented.

Essential in the role:

* PhD, or equivalent, in bioinformatics, mathematics, computer science, statistics, engineering or the life sciences
* Expertise in one or more of the core competency areas: DNA/RNA sequence analysis, next generation sequencing analysis, multivariate and/or high dimensional data analysis (-omics), ontologies, data management, machine learning, statistical modelling,
* Experience with relevant software tools such as R, Python, Shiny, Spotfire, Java, C/C++, SQL/NoSQL/RDF, JavaScript
* Basic understanding of molecular biology, cell biology, and human physiology


The successful candidate will demonstrate a passion for driving scientific questions and is capable of receiving and analyzing input from multiple fields and deciding on focused course of action. You should also be able to work independently and have a positive, result-oriented and problem-solving attitude. Excellent English is required, both spoken and written, and ability to operate effectively in a multi-disciplinary research environment. We also believe that you enjoy teamwork, have a collaborative nature and will be an encouraging colleague to all.

Why AstraZeneca?
AstraZeneca is a global, innovation-driven biopharmaceutical company that focuses on the discovery, development and commercialization of prescription medicines for some of the world's most serious diseases. In addition to being one of the world's leading pharmaceutical companies, AstraZeneca is proud to provide a unique workplace culture that inspires innovation and cross-boundary collaboration. Within this environment employees are empowered to express diverse perspectives, and are made to feel valued, energized and rewarded for their ideas and creativity.

Does this sound like your next position? Apply now!

We will continuously review applications and look forward to your application no later than February 28th, 2021.

For more information about the position please contact hiring manager Fredrik Karlsson at fredrik.h.karlsson@astrazeneca.com.

Additional information:
Our Gothenburg site: https://www.astrazeneca.com/our-science/gothenburg.html
Life in Gothenburg: https://www.movetogothenburg.com/