Senior Biotransformation Scientist

Are you an experienced Biotransformation Scientist with expertise in mass spectrometry? Would you like to apply your expertise in a company that is accelerating innovative science and turn ideas into life changing medicines? Join us to be part of the development of future treatments of Cardiovascular, Renal and Metabolic diseases!

Working at AstraZeneca means being entrepreneurial, thinking big and working together to make the impossible a reality. We are now recruiting a highly skilled and passionate scientist with expertise in Biotransformation to join the DMPK Drug Design and Biotransformation team within the Early Cardiovascular, Renal and Metabolism (CVRM) therapeutic area at AstraZeneca. The position is placed at AstraZeneca's dynamic R&D site in Gothenburg, Sweden.

Early CVRM is one of the three main therapeutic research areas within AstraZeneca which deliver candidate drugs into late-stage clinical development. Early CVRM is a global function with research units in Gaithersburg, US, Cambridge, UK and Gothenburg, Sweden. DMPK Drug Design and Biotransformation team is part of the DMPK department and based in AstraZeneca's world-class R&D center in Gothenburg Sweden. DMPK interacts with other functions in supporting CVRM projects all along the value chain, from target selection all the way to market launch and Life cycle management.

What you'll do

As a Senior Biotransformation Scientist, you will be part of a strong team at the forefront of DMPK science focusing on the biological fate of molecules in preclinical species and humans.

We look to you to act as an expert in your area providing proficient scientific advice on drug disposition to project teams. This is a lab-based role, where you will study and elucidate mechanisms and pathways that determine metabolism and disposition of drug substances. You are responsible for identification of drug metabolites in biological samples and will provide significant input from target identification to life-cycle management.

Essential for the role

We are looking for an expert in structure elucidation of metabolites, with basic understanding of the mechanisms of P-450 oxidations/reactive metabolites and how this may influence drug design. You need to have in-depth experience of high-resolution accurate mass MS, including competence to handle small molecules and/or drug candidates beyond small molecules, such as peptides, proteins and/or oligonucleotide-based drugs. You also need to have excellent knowledge of sample preparation of biofluids, liquid chromatography and mass spectrometry and have technical skills to operate and perform regular maintenance and elementary trouble shooting.

You also have:

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PhD or equivalent degree in relevant discipline (Biotransformation, Medicinal Chemistry, Organic Chemistry or Analytical Chemistry)

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Scientific leadership, evidenced by a publication track record
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Good communication skills in English, both verbal and in writing
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Excellent interpersonal skills

Desirable for the role

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Knowledge of guidelines and policies in drug development regarding biotransformation, including MIST
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Experience from industry environment

So, what's next?

Are you already imagining yourself joining our team? Good, because we can't wait to hear from you!

For more information about the position please contact recruiting manager Marie Ahlqvist at marie.ahlqvist@astrazeneca.com

Welcome with your application no later than Dec 12, 2021

Where can I find out more?

Read more about CVRM therapeutic area: https://www.astrazeneca.com/our-therapy-areas/cardiovascular-renal-and-metabolism.html

Make a move to Global Gothenburg: https://www.youtube.com/watch?v=c-Iqbb4aw38

Our Gothenburg site: https://www.astrazeneca.com/our-science/gothenburg.html

Life in Gothenburg: https://www.movetogothenburg.com/

Why AstraZeneca?

Our Gothenburg site is one of AstraZeneca's three strategic science centres. We thrive in a multinational environment working cross-functionally across the globe with AstraZeneca colleagues as well as academic and industry partners. Our way of life is to foster a working environment that nurtures, collaboration, openness and innovation. Therefore, we have created space for meetings, socializing and relaxation, where spontaneous meetings can give birth to new innovations.