(Senior) Clinical Pharmacometrician

(Senior) Clinical Pharmacometrician, CVMD Quantitative Clinical Pharmacology - Early Clinical Development

Do you have expertise and experience in mathematical modelling and simulation and its application in drug development, plus a pharmaceutical industry R&D background? Do you have a good understanding of the concepts of pharmacokinetics and drug disposition? If you're a talented and engaged individual, this is an opportunity to join AstraZeneca as a (Senior) Clinical Pharmacometrician in Gothenburg supporting projects within the therapy area of Cardiovascular and Metabolic Disorders

AstraZeneca is a world-leading pharmaceutical company, we focus on discovering and developing medicines that make a real difference to millions of patients. We are building a state-of-the-art quantitative clinical pharmacology group with a diverse and uniquely skilled team of pharmacometricians in Gothenburg, where two of our key therapeutic areas are located. You'll thrive in an environment that inspires innovation, encourages multidisciplinary team-working and collaboration with academia, and rewards original scientific thinking.

Main duties and responsibilities
Working closely with clinical pharmacology scientists, physicians and other scientists, you'll apply modelling to support the design and interpretation of clinical studies and influence key decisions in early and late clinical development.

The work includes integration of relevant data, such as dose information, pharmacokinetics, biomarkers and clinical endpoints within and across studies, compounds and development stages. Support to informative trial designs using simulations and efficient modeling statistics is an important focus area for us. An area to grow is quantitative systems pharmacology and mechanistic modelling approaches for more informative translation of disease and drug knowledge. In collaboration with clinical pharmacology scientists, you'll represent Quantitative Clinical Pharmacology and be responsible for identifying and executing modelling to support model based drug development. You will communicate your findings to other scientists within and outside of AstraZeneca and publish them in peer reviewed journals.

Essential requirements
You must have:
PhD degree preferred or equivalent relevant experience in quantitative science
Strong quantitative modelling skills, e.g. expert knowledge in mathematics, statistics, mechanistic systems pharmacology modelling, quantitative translational scaling, model-based meta-analyses
Background and a comprehensive understanding of clinical pharmacology aspects of drug development
Experience in pharmaceutical R&D
Working knowledge of pharmacokinetics and its clinical application
Biological understanding of disease and drug action
Excellent oral and written communication skills.
You'll need real passion for your subject, along with a high level of integrity, plus the ability to work in a multi-disciplinary setting that comprises a number of specialists in their fields, including physicians, scientists and statisticians.

Desirable requirements
You will ideally have:
Recognised scientific expertise demonstrated by scientific publishing in the field of clinical pharmacology
Early or late phase clinical development experience/awareness.

More information
Salary: Competitive
Location: Gothenburg, Sweden

FOR FULL JOB DESCRIPTION AND TO APPLY, please visit www.astrazeneca.se/karriar