Senior in vitro ADME scientist

Are you an in-vitro ADME specialist with experience in drug discovery? Would you like to apply your expertise in a company that is accelerating innovative science and turn ideas into life changing medicines? Join us to be part of the development of future treatments of Cardiovascular, Renal and Metabolic diseases!

We are now recruiting a senior ADME scientist to join the DMPK department within the Early Cardiovascular, Renal and Metabolism (CVRM) therapeutic area at AstraZeneca in Gothenburg, Sweden.

We continually push the boundaries of science to deliver medicines that treat diseases across our main therapy areas. Through our integration with Alexion, this now includes expanding the limits of scientific research to better understand rare diseases and to discover new life-changing treatments for them.

As a Senior in vitro ADME scientist you will be part of a team at the forefront of DMPK science working with all aspects of drug disposition, including subcellular drug handling, and relating to drug effects. We are accountable for the breadth of the CVRM drug portfolio, and this role will enhance our team to in the area of rare diseases. You will have the opportunity to contribute to the discovery of new life changing medicines for patients and demonstrate and witness what science can do.

What you'll do

We'll look to you to act as an expert in your area providing proficient scientific advice on all aspects of drug disposition to project teams. You will provide significant input into the practical delivery of project goals across all modalities in the portfolio as well as develop and implement novel approaches. Responsibility includes:

* Be responsible for the design, conduct, interpretation and reporting of in vitro ADME studies. You will apply novel in-vitro DMPK science, including e.g. 3D-cell cultures, across drug discovery and development to support design and project progression.
* Provide mentorship and laboratory supervision internally of less experienced scientists and training and development of scientific talents.
* Provide scientific leadership by leading and driving collaborations with key academic centres and by presenting work through lectures and publications in top-tier scientific journals.
* Identify improvements in technologies that can be successfully applied to a highly competitive drug discovery or development paradigm that contributes to achievement of short and long term business goals and influences strategic direction.
* May be part of cross-functional work-streams and lead the development and implementation of DMPK scientific strategies, and act as a catalyst for scientific debate within the AstraZeneca science community.

Essential requirements

* PhD or equivalent in relevant field, and at least three years of experience relevant to the position
* Broad knowledge about ADME processes and relevant in-vitro models of drug disposition, and track record in development, characterization and application of translatable in-vitro models beyond small molecule drugs
* Versatile in in-vitro laboratory skills (e.g. handling and culturing of primary human hepatocytes and other human cells and tissues, molecular biology methods and image analysis, enzyme and transporter kinetic studies)
* Scientific leadership, evidenced by a publication track record
* Excellent interpersonal skills and good communication skills in English, both verbal and in writing

Desirable requirements

* Knowledge in omics technologies and bioinformatics
* Experience in bioanalytical techniques, e.g. LC-MS
* Expertise in automation equipment and automated processing

So, what's next?

Are you already imagining yourself joining our team? Good, because we can't wait to hear from you!

For more information about the position please contact hiring manager Constanze Hilgendorf Constanze.hilgendorf@astrazeneca.com. Welcome with your application no later than February 28, 2022.

Where can I find out more?

Our Gothenburg site: https://www.astrazeneca.com/our-science/gothenburg.html

Global Gothenburg: https://www.astrazeneca.se/om-oss/verksamheten-i-sverige/goteborg/relocate-to-gothenburg.html

Life in Gothenburg: https://www.movetogothenburg.com/

Why AstraZeneca?

Our Gothenburg site is one of AstraZeneca's three strategic R&D centers. With more than 2,400 employees from over than 50 countries, our vibrant Gothenburg site is a truly inspiring place to work. Here, the history and future of scientific breakthrough come together. We believe that the diversity of our people is crucial to bringing new discoveries to life.

You will be offered a competitive salary and excellent benefits, such as extra paid Holiday, Private Medical Benefits, On-site exercise and much, much more.