Senior In vitro Scientist - Cellular imaging

Are you an experienced scientist in the field of cell biology and advanced cell culture? Do you have experience of cellular imaging and other technologies for phenotype characterization that you are keen to apply for the development of novel cell-based therapies? Join us and be a key player in the build of our Biopharmaceuticals R&D Cell Therapy department. Together we will push the boundaries of Science!

At AstraZeneca, you will be empowered to be innovative and creative where difference is valued. We thrive in a place where the brightest and most curious minds seamlessly come together in our inclusive environment. The role is placed at AstraZeneca's dynamic R&D site in Gothenburg, Sweden, where you will work in an international setting at the fore front of Cell Therapy science.

Biopharmaceuticals R&D is committed to the development of next generation innovative medicines, and we are building a Cell Therapy department with the goal to establish AstraZeneca as a world-leader in Cell Therapy across disease areas within Cardiovascular, Renal and Metabolism (CVRM) and Respiratory and Inflammation (R&I). The department will bring together >50 specialists to support the organization with cell therapy expertise and capabilities, and we are working in close collaboration with experts across AstraZeneca globally to leverage the existing and emerging platforms in cell technologies, new modalities, universal cell lines and CRISPR-mediated genome editing.

What you'll do

This role provides an opportunity to work in an international, highly cross disciplinary environment with ground-breaking techniques and technologies within areas such as stem cell biology and precise genome editing. You will work together with our in vitro scientists and collaborate with disease area specialists, in vivo scientists and advanced imaging experts to develop our scientific capabilities and ensure efficient progress of Cell Therapy projects.

The role is focused on laboratory-based activities and you will use your scientific expertise to design and execute experiments and to deliver high quality data. Your biggest impact will be through practical and scientific contributions to support projects in compliance with AstraZeneca corporate responsibility, policies and relevant safety standards. You will be working in a flexible project-driven organization with several ongoing projects in parallel.

In this role it is essential to have good social and communication skills, be collaborative and a strong team player. You should be able to work independently, take own initiatives and have a positive, goal oriented and problem-solving attitude. Good organizational, data management and documentation skills are required, and you should be comfortable in presenting your results internally as well as at external meetings.

Accountability includes:

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Design and perform experiments in vitro to generate cell populations of therapeutic relevance.
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Characterize and quantify cell phenotype/identity using imaging-based readouts as well as other readouts as needed.
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Develop and troubleshoot antibody staining and imaging protocols.
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Develop and troubleshoot protocol for in vitro culture and differentiation of various cell types including primary cells and pluripotent stem cells.
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Independently analyse and report data to support project decisions and communicate relevant information between distinct projects within the bioscience department as well as across other functions.

Essential for the role

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Ph.D. in Cell Biology or a related field with relevant academic or industrial experience.
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Minimum 5+ years' experience of in vitro cell culture (primary and/or pluripotent stem cells).
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Hands-on experience in using automated (e.g. Yokogawa, Molecular Devices) and conventional fluorescent and confocal imaging systems.
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Experience of image analysis and data analytics tools.

Desirable for the role

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Hands-on experience of hESC or hiPSC culture and differentiation.
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Experience of primary or stem cell culture in 3D.
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Experience of imaging complex cell structures such as microtissues and organoids.
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Experience in cellular analysis platforms like flow cytometry or qPCR.

So, what's next?

Are you already imagining yourself joining us? Good, because we can't wait to hear from you!

Welcome with your application no later than October 2nd 2022. We will review the applications continuously so please apply at your earliest convenience.

Where can I find out more?

Cell Therapy Biopharmaceuticals R&D: Link

Global Gothenburg: Link

Our Gothenburg site: Link

Life in Gothenburg: Link

Why AstraZeneca?

Our Gothenburg site is one of AstraZeneca's three strategic R&D centers. With more than 2,400 employees from over than 50 countries, our vibrant Gothenburg site is a truly inspiring place to work. Here, the history and future of scientific breakthrough come together. We believe that the diversity of our people is crucial to bringing new discoveries to life.