Senior Research Scientist

Senior Research Scientist, Translational Genomics In Vivo Physiology

The Discovery Sciences, Translational Genomics department is looking for a senior research scientist to be part of our in vivo physiology discipline within the Transgenic Models team. The position is based at the AstraZeneca R&D site in Gothenburg, Sweden and we are seeking a scientific and technical specialist in the animal in vivo physiology field. As a successful candidate you are experimentally focused, with strong troubleshooting skills and adept at putting ideas into practice. You will perform experimental strategies and make significant contributions to the practical delivery of projects in compliance with AstraZeneca corporate responsibility policies and relevant safety standards and of central importance is experience with murine in vivo experimentation. You will have good social and communication skills, be collaborative and be a strong team player. Candidates should be able to work independently with a positive, goal oriented and problem-solving attitude. Good organizational skills are required and you should be comfortable in presenting your results. Excellent English is required, both spoken and written.


SPECIFIC RESPONSIBILITIES
• PERFORM STUDIES WITHIN THE IN VIVO PHYSIOLOGY DISCIPLINE WITH FULL ENGAGEMENT WITH STAKEHOLDERS TO ENSURE THE DISCIPLINE OPERATES AT THE SCIENTIFIC FOREFRONT, USING WORLD LEADING TECHNOLOGIES AND INFRASTRUCTURE TO SUPPORT ALL CORE DISEASE AREAS
• ENSURE THAT STUDIES ARE CONDUCTED WITH QUALITY, DEDICATION AND DATA DELIVERED ACCORDING TO STIPULATED TIME LINES AND PROJECT REQUIREMENTS
• COMPILE, INTERPRET, PRESENT AND DISCUSS DATA WITH KEY PROJECT TEAMS AND STAKEHOLDERS
• ACTIVELY PROMOTE THE IN VIVO PHYSIOLOGY DISCIPLINE ACTIVITIES TO ENSURE VISIBILITY IN THE WIDER ASTRAZENECA ORGANIZATION
• HANDS ON ACTIVITY IN THE LAB WHEN REQUIRED FOR TIMELY PROJECT PROGRESSION

THE FOLLOWING SKILLS WOULD BE A DEFINITE ADVANTAGE:
• EXPERIENCE IN METABOLIC PHENOTYPING PLATFORMS AND ANALYSIS OF METABOLIC FUNCTION IN MICE E.G. INDIRECT CALORIMETRY AND INTRAPERITONEAL GLUCOSE TOLERANCE TESTS (IPGTT) TO DIAGNOSE METABOLIC FUNCTION IN GENETICALLY-ENGINEERED MICE AND HYPERINSULINEMIC-EUGLYCEMIC CLAMPS.
• EXPERIENCE OF MURINE BEHAVIOURAL PHENOTYPING
• EXPERIENCE OF STEROTACTIC BRAIN INJECTIONS IN MICE
• EXPERTISE IN THE GENERATION AND CHARACTERIZATION OF TRANSGENIC ANIMAL MODELS
• USE OF VIRAL VECTORS AND NON-VIRAL DELIVERY VEHCILES FOR IN VIVO GENETIC ENGINEERING

MINIMUM REQUIREMENTS –EDUCATION AND EXPERIENCE
You should have a Ph.D degree or corresponding experience in a relevant scientific discipline with experience in drug discovery or, alternatively, a first degree and significant relevant experience in drug discovery.