Senior Research Scientist - Analytical Chemist

AstraZeneca is one of the world's most exciting biopharmaceutical companies. From scientists to sales, lab techs to legal, we're on a mission to turn science into life-changing medicines that improve patients' lives and benefit society.

AstraZeneca R&D, Physical & Analytical Chemistry, Gothenburg, Sweden now seek to recruit a Senior Research Scientist responsible for Analytical Research of oligonucleotides in the Therapeutic Area Respiratory and Immunology (R&I).

AstraZeneca is committed to the development of the next generation innovative respiratory medicines. Respiratory & Immunology is one of AstraZeneca's three therapy areas and is a key growth driver for the Company. Building on our 50-year heritage, we are an established leader in respiratory care across inhaled and biologic medicines.

The department of Medicinal Chemistry in the therapeutic area of Respiratory & Immunology is focused on the delivery of Small Molecule (SM) and New Modalities (NM) clinical candidates. Its Physical and Analytical Chemistry team, crucial for the delivery of clinical compounds, is working with a strong research focus in close collaboration with Medicinal Chemists and scientists in all other neighboring departments. We jointly aim at the discovery of the respiratory medicines of the future.



Major Duties and Responsibilities

We are looking for a candidate with a background in Analytical Chemistry and documented expertise in the characterisation of synthetic oligonucleotides. In this role, the candidate will support synthesis and drug discovery projects with state-of-the art analytical characterisation of oligonucleotides, mainly by MALDI-MS and LC/MS. As an experienced analytical chemist, the candidate shows the ability to engage and collaborate across boundaries with a problem-solving attitude and delivery focus.

Your responsibilities will include:

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Efficient support of AZ oligonucleotide portfolio applying MALDI-MS and LC/MS methods
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Driving internal build of analytical methods for oligonucleotide profiling
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Effective collaboration with project team members and colleagues in Medicinal Chemistry



Essential requirements

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PhD in Analytical Chemistry
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Documented expertise in MALDI-MS, LC/MS and high-resolution mass spectrometry (theoretical in-depth knowledge and practical expertise)
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Demonstrated expertise in MS characterization of oligonucleotides (MS/MS CID, ETD and MALDI-MS) is a significant bonus.
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Experience and knowledge of separation techniques beyond RP-UPLC (such as Gel electrophoresis, capillary electrophoresis, ion-exchange chromatography and size exclusion chromatography) is a bonus.
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Strong scientific curiosity in novel technology and methods
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Excellent communication and collaboration skills



Why AstraZeneca?

At AstraZeneca we're dedicated to being a Great Place to Work. Where you are empowered to push the boundaries of science and unleash your entrepreneurial spirit. There's no better place to make a difference to medicine, patients and society. An inclusive culture that champions diversity and collaboration, and always committed to lifelong learning, growth and development. We're on an exciting journey to pioneer the future of healthcare.

We would like to know more about you. If you are interested, apply now!

We welcome your application no later than 30 April 2021



Where can I find out more?

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