Senior Research Scientist, Bioscience In Vivo

Are you an experienced Scientist ready to apply your skills in a diverse and dynamic company? If you can envision providing scientific expertise in a role that can impact patients' lives - join us now!

At AstraZeneca, we believe in the potential of our people and you'll develop beyond what you thought possible. We make the most of your skills and passion by actively supporting you to see what you can achieve no matter where you start with us.

We are now looking to recruit an In Vivo Scientist with a drive for innovation and idea generation as well as excellent laboratory skills to join the Bioscience In Vivo Department within the Early Respiratory and Immunology R&D unit located in Gothenburg, Sweden.

Respiratory & Immunology is one of AstraZeneca's main therapy areas. From a research perspective we work to understand, treat, modify and ultimately cure respiratory disease with an emphasis on four diseases with significant unmet medical need; asthma, COPD, Idiopathic Pulmonary Fibrosis (IPF) and Chronic Cough.

The successful candidate will join a highly motivated team that works closely together with other departments focusing on Target Translational Science, Bioscience In vitro assays and Drug Metabolism/Pharmacokinetics to support discovery projects and to drive new exciting research. Are you ready to join us?



What you'll do

Contribute as a vital member of the in vivo team to progress our drug discovery projects. You will actively take part in scientific discussions, represent the department in project meetings, gain input from other functions and incorporate in vitro as well as pharmacokinetic data in the experimental design.

This is a partly lab-based role where you will be actively involved in the execution of the experiments, with responsibility to coordinate, perform and analyse in vivo experiments. You will independently assess and report data with a clear understanding of its reliability, interpretation of findings and draw appropriate conclusions. We are looking for a team player with experience in animal hands-on work, skills in cellular- and molecular biology techniques and knowledge in pre-clinical drug discovery.


Essential for the role

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PhD in a relevant discipline (area of Bioscience) ideally complemented by a number of years working in a drug discovery environment
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Excellent hands-on in vivo skills within the respiratory field and the ability to independently design and perform disease and mechanistic models, including administration of candidate drugs and collecting biological samples
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Respiratory disease knowledge, including target and mechanism knowledge (COPD, asthma, cough, IPF, tissue regeneration) and basic understanding of PKPD relationships
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Be respectful, communicate openly and show effective collaborative behavior to obtain high quality study results
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Excellent written and oral communication skills, including presentation skills. You are organized and incorporates the views of others in your communication and collaboration
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Experience of maintaining the highest standards of welfare and ethical compliance as well as ensuring the integrity of the data generated. Familiar with using Good Statistical Practice in animal research and applying the 3R's (reduction, refinement and replacement) across the full range of studies
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Good understanding of pharmacology, physiology and immunology



Desirable for the role

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Valid education required for compliance to work with live animals in Sweden
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Experience in various cellular and molecular biology techniques for the measurement of protein expression and activation (eg ELISA,western blot, FACS, Meso Scale Discovery (MSD) technology platform), and RNA (qRT-PCR, RNASeq)
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Knowledge in immunohistochemistry, histology scoring and histomorphometry
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Understanding and experience in molecular biology
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Good written and oral communication skills in Swedish and experience in writing ethical applications for animal work in Sweden



At AstraZeneca when we see an opportunity for change, we seize it and make it happen, because any opportunity no matter how small, can be the start of something big. Delivering life-changing medicines is about being entrepreneurial - finding those moments and recognising their potential. Join us on our journey of building a new kind of organisation to reset expectations of what a bio-pharmaceutical company can be. This means we're opening new ways to work, pioneering groundbreaking methods and bringing unexpected teams together. Interested? Come and join our journey.



So, what's next!

Are you already imagining yourself joining our team? Good, because we can't wait to hear from you. Welcome with your application no later than 30 April, 2021



Where can I find out more?

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Follow AstraZeneca on LinkedIn https://www.linkedin.com/company/1603/
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