Senior Research Scientist / Cellbiologist for AstraZeneca

Presentation

For AstraZeneca we are now looking for a Senior Scientist in the field of Cellbiology. The consultant assignment will start immediately and go on until 2017-09-30 will possibility for extension.

Interviews and selections are held continously so please apply today!

Arbetsuppgifter

You will join the Discovery Sciences organization, working within a first-class scientific environment to support drug discovery. The Reagents and Assay Development department (RAD) of Discovery Sciences, is responsible for the generation of novel cellular reagents and assays to support projects in all phases of the drug discovery pipeline. We are seeking a Senior Research Scientist to join our cellular RAD team in Gothenburg Sweden, where we focus on delivering reagents and assays primarily for Cardiovascular and Metabolic diseases and Respiratory and Autoimmunity.

Your main tasks will be:

- cell line generation using traditional and precise genome editing approaches
- cellular assay development
- target identification and target validation
- to be an authority in the arena of cell science and precise genome editing
- coach and support more junior scientists by advising and challenging them and by providing expert advice
- develop cellular reagents for target based approaches and phenotypic assays, target identification, target validation
- perform confirmation of cellular/genetic manipulation and functional validation of engineered cells
- perform target identification and target validation studies in early projects
- development of stable cell lines utilising traditional, viral and Precise Genome Editing (CRISPR) techniques
- transient and stable transfection utilising different technologies such as electroporation (Maxcyte, Nucleofector, Amaxa), lipid and PEI
- viral tools for expression and cell line generation
- isolation of clonal cell lines
- MACS, FACS, limiting dilution
- design and generation of Precise Genome Editing (CRISPR) strategies
- tools and reagents required for cell line generation, target identification and target validation
- genetic (ddPCR, NGS, AmpliconSeq) characterization of engineered cell lines
- unctional (phenotypic assays, expression analysis) characterization of engineered cell lines
- culturing and functional characterization of recombinant cell lines, primary cells and iPSC in both small (multi-well plates) and large (cell factories) scale
- drug discovery and cell deliverables in an industrial or biotech setting
- cell-based assays for drug discovery would be beneficial

It is essential to have good social and communication skills, be collaborative and a strong team player.You should be able to work independently, take own initiatives and have a positive, goal oriented and problem solving attitude. Good organisational skills are required and you should be comfortable in presenting your results. Excellent English is required, both spoken and in writing.

Utbildning/erfarenhet

You should have a Ph. D. degree or corresponding experience in a relevant scientific discipline with experience in drug discovery or, alternatively, a first degree and significant relevant experience in drug discovery.

Experience of development of stable cell lines utilising traditional, viral and Precise Genome Editing (CRISPR) techniques is highly meritating as well as transient and stable transfection utilising different technologies such as electroporation (Maxcyte, Nucleofector, Amaxa), lipid and PEI, knowledge of viral tools for expression and cell line generation, Isolation of clonal cell lines MACS, FACS, Expert knowledge in the design and generation of Precise Genome Editing (CRISPR) strategies, tools and reagents required for cell line generation, target identification and target validation, Genetic (ddPCR, NGS, AmpliconSeq) characterization of engineered cell lines, experience from Functional (phenotypic assays, expression analysis) characterization of engineered cell lines and Culturing and functional characterization of recombinant cell lines, primary cells and iPSC in both small (multi-well plates) and large (cell factories) scale.
• Experience of drug discovery and cell deliverables in an industrial or biotech setting
• Practical knowledge of cell-based assays for drug discovery would be beneficial


Förmåner

We take good care of our consultants and we offer social activities, as well as help in planning your future career. Your consultant manager is well experienced from your field, and knows how to get the most out of your assignment.

As a Poolia employee, you are included in the requirements concerning agreements on terms of employment by Unionen. Moreover, you get a grant for working out at your choice of place. You are also covered by a health insurance.

Företagsbeskrivning

Poolia Life Science can offer several opportunities for skilled people with a background in biochemistry, chemical engineering or science. We work with Sweden’s leading pharmaceutical and life science companies. So whether you’re interested in research, regulatory affairs, quality assurance, environmental and quality control, sales and marketing, or just want a career change, we have the job for you.

Working as a consultant suits whoever wants to get a lot of experience in a short period of time. We offer you the chance to work with well-known brands at renowned companies where you can develop your skills. If you’re looking for a world of exciting assignments and new contacts, you’ll like being a consultant.

AstraZeneca is a major international healthcare company engaged in the research, development, manufacture and marketing of prescription pharmaceuticals and the supply of healthcare services. But we are more than one of the world’s leading pharmaceutical companies - at AstraZeneca, we are proud to have a unique culture that inspires innovation and collaboration. Here, employees are empowered to express diverse perspectives - and are made to feel valued, energized and rewarded for their ideas and creativity.

Sluttext

Please apply by registering your CV here on our website. Click on the "Ansök" button to the right. It is our recommendation that you register as much information as possible and that you attach a complete CV-document. Please check that your correct e-mail address is registered.

Poolia is a registered staffing agency, meaning that we comply with the requirements set by Bemanningsföretagen - the Swedish Association of Staffing Agencies.

Language

en-GB