Senior Research Scientist, Cellular Assay Development

We have an exciting opportunity for you to join Discovery Sciences’ Discovery Biology Department as a lab-based scientist in the Cellular Assays Team developing state-of-the-art cell-based screening assays and detailed biological mechanism-of-action studies to support projects in all phases of AstraZeneca’s drug discovery pipeline with a significant focus in RIA and CVRM disease areas. Specifically, the successful candidate will take a lead scientific role in applying their skills using imaging technologies and developing high content assays.

Om tjänsten
As a Senior Research Scientist in cellular assay development in Gothenburg, Sweden, you’ll play a pivotal role in channelling our scientific capabilities to make a positive impact on changing patients’ lives. You will work within Discovery Sciences, part of AstraZeneca’s BioPharmaceuticals organisation, which focuses on scientific advances in established and emerging medicine formats and drug discovery technologies across therapeutic areas including, respiratory and inflammation (RIA), cardiovascular and metabolism (CVRM).

Dina arbetsuppgifter i huvudsak
Main Duties and Responsibilities:
• Lab-based scientist utilizing expertise in cellular assay development; independently designing, developing and validating assays for implementation in drug discovery projects, while incorporating the views of others
• Work in partnership with colleagues in the High Throughput Screening and Mechanistic Biology & Profiling teams and across the organisation
• Design and implement work-plans to agreed timelines to meet project objectives, including delivery of more than one agreed area of work in parallel
• Be an effective member of Drug Discovery Project Teams, contributing novel ideas and using judgement and knowledge to influence the work of the project
• May lead one or more aspects of scientific discipline within the team
• Maintain an awareness of current developments in the literature and contribute to the continuous capability enhancement process by identifying opportunities where improvements can be made
• Achieve personal scientific visibility through project contributions and internal presentations at departmental or functional meetings; and external scientific visibility through poster and oral conference presentations and authorship on peer-reviewed publications

Vem är du?
Essential Requirements:
• PhD in Biology, Pharmacology, Cell biology or a related discipline or a BSc/MSc degree with significant relevant experience, preferably in the pharmaceutical or biotechnology industry
• Strong experience in cellular biology techniques applied to development of physiologically relevant cellular assays
• Expertise in the design, development and validation of cellular imaging assays for compound profiling
• Experience in advanced and automated fluorescent based imaging platforms
• Experience in use and development of scripts for quantitative image analysis

Desirable Requirements:
• A practical understanding of a wide range of cellular assay methods and technologies (e.g., fluorescence, luminescence, target engagement techniques, plate-based automation) as applied to a range of biological targets for compound profiling and screening
• Good publication records in peer-reviewed journals preferably in the field of RNA degradation biology
• Excellent problem-solving skills, strong delivery focus and communication skills
• Research experience in RIA and/or CVRM diseases
• Excellent team working and networking skills with experience of interacting effectively across interfaces of discipline, culture, and expertise

Om verksamheten
At AstraZeneca we work together across global boundaries to make an impact and find answers to challenges. We do this with the upmost integrity even in the most difficult situations because we are committed to doing the right thing. We continuously forge partnerships that help pursue world-class medicines in new ways, combining our people’s exceptional skills with those of people from all over the globe.

AstraZeneca is an equal opportunity employer. AstraZeneca will consider all qualified applicants for employment without discrimination on grounds of disability, sex or sexual orientation, pregnancy or maternity leave status, race or national or ethnic origin, age, religion or belief, gender identity or re-assignment, marital or civil partnership status, protected veteran status (if applicable) or any other characteristic protected by law.



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