Senior Research Scientist - Cellular assay development PROTAC

Do you want be a part of the development of state-of-the-art cell-based screening assays to support PROTAC development in all phases of AstraZeneca's drug discovery pipeline? Do you also feel passionate about working in a lab environment together with a great team of colleagues? If so, this might be your next challenge!

As a Senior Research Scientist in cellular assay development in Gothenburg, Sweden, you'll play a pivotal role in channeling our scientific capabilities to make a positive impact on changing patients' lives. You will work within Discovery Sciences, part of AstraZeneca's BioPharmaceuticals organisation, which focuses on scientific advances in drug discovery across therapeutic areas including, respiratory and inflammation (R&I) and cardiovascular and metabolism (CVRM).

What you'll do:
This is an exciting opportunity for you to join us as a lab-based scientist to develop state-of-the-art cell-based screening assays. These assays will be used in detailed biological mechanism-of-action studies to support PROTAC development in all phases of AstraZeneca's drug discovery pipeline.

Essential for this position:

* PhD in Biology, Pharmacology, Cell biology or a related discipline or a BSc/MSc degree with significant relevant experience, preferably in the pharmaceutical or biotechnology industry
* Strong experience in cellular biology techniques applied to development of physiologically relevant cellular assays including imaging assays
* A practical understanding of a wide range of cellular assay methods and technologies including imaging (e.g., fluorescence, luminescence, target engagement techniques, plate-based automation) as applied to biological targets for compound profiling and screening

Desirable for this position:

* Expert of the biology of Ubiquitin-Proteasome System (UPS)
* Expertise in a range of cell biology techniques, to include cloning, transfection methods, gene expression knock-down (RNAi or other) and endogenous gene tagging
* Expertise in the design, development and validation of cellular assays for compound profiling including PROTACS
* Good publication records in peer-reviewed journals preferably in the field of UPS biology
* Experience in use and development of scripts for quantitative image analysis

To be successful in the role as Senior Research Scientist we believe you are a highly motivated scientist with a passion to make a difference for patients all over the world. Along with this we see you as a person who enjoys collaboration and team working, who holds networking skills with experience of interacting effectively across interfaces of discipline, culture, and expertise. This goes hand in hand with your problem-solving skills, strong delivery focus and communication skills.

Why AstraZeneca?
At AstraZeneca we work together across global boundaries to make an impact and find answers to challenges. We do this with the upmost integrity even in the most difficult situations because we are committed to doing the right thing. We continuously forge partnerships that help pursue world-class medicines in new ways, combining our people's exceptional skills with those of people from all over the globe.

Our Gothenburg site: https://www.astrazeneca.com/our-science/gothenburg.html
Life in Gothenburg: https://www.movetogothenburg.com/

Does this sound like the job and place for you? Apply today! We look forward to your application no later than 5th July, 2020.

For further details around this position you are welcome to contact the recruiting manager Sam Barichievy, email: Sam.Barichievy@astrazeneca.com