Senior Research Scientist - DNA encoded library synthesis

Do you have hands-on experience and great knowledge with the synthesis of DNA encoded libraries? Are you interested in establishing and developing our new DEL synthesis lab at a company where we are committed to lifelong learning, growth and development? If yes, this might be the role for you!

We are looking for a specialized Synthetic Chemist that will play an important part in our iLAB team, focusing on the synthesis of novel DNA encoded libraries (DEL). You will have the opportunity to drive and influence the DEL synthesis capabilities in our newly created lab at AstraZeneca in Gothenburg, Sweden and contribute to the production of a proprietary compound collection based on DEL.

We are a global, science-led BioPharmaceutical business and our innovative medicines are used by millions of patients worldwide. With our ground-breaking pipeline comes a bright future - a secure job, exciting opportunities and varied work. You will be valued. Not only for your unique contribution, skills and background, but because we recognize people are our greatest asset. Here we are dedicated to being a Great Place to Work.

Thrive in a place where the brightest and most curious minds seamlessly come together in our inclusive environment.

What you will do:
This is an exciting role where you will contribute from an early stage to the development of the newly created DEL synthesis lab capabilities at AstraZeneca Gothenburg. You will design and synthesize DNA encoded libraries - and use and develop currently available chemistry automation for DEL synthesis. You will also contribute to the continuous improvement of the DEL synthesis platform by developing and applying new, groundbreaking synthetic approaches for on-DNA chemistry and by evaluating new technologies.

In your daily work you will troubleshoot laboratory-based problems and make a significant contribution to the delivery of the team. As a DEL Chemist, you will maintain access to the best internal and external science and enhance business reputation internally and externally through peer-reviewed publications and oral/poster presentations.

Essential in the role:
You're a chemist with a track record of applying innovative chemistry solutions, with resulting impact in project delivery. You also have:

* Ph.D. in a relevant chemistry field, or a Master degree in chemistry with minimum 5 years' experience in synthetic organic chemistry.
* Hands-on experience with on-DNA synthesis and/or synthesis of DNA encoded libraries.
* Expertise in theoretical and practical organic synthesis, retrosynthesis, compound route design, purification and analytical sciences.
* Expertise in parallel chemistry.
* Knowledge of basic molecular biology techniques e.g gel electrophoresis, DNA ligation, PCR.
* Advanced knowledge of modern chemical literature, chemical technologies and applying new ideas to project delivery.
* A track record of driving innovation in chemistry related sciences.

The successful candidate should be motivated to work effectively in hardworking teams and demonstrate ability to work across scientific fields to get results. We also believe that our candidate have effective levels of communication, a scientific drive and a high interest in working with organic chemistry and molecular biology techniques.

Desirable in the role:

* Experience in the development of on-DNA chemistry.
* Experience in methods development.
* Experience with chemistry automation.
* Knowledge in designing high-throughput chemistry and/or library synthesis experiments using bespoke design software.
* Knowledge of medicinal chemistry.

We also believe that the successful candidate have a detailed understanding of the chemical sciences and how they contribute and influence drug discovery together with knowledge of the drug discovery process.

Why AstraZeneca Gothenburg?
With more than 2,400 employees from over 50 countries, our vibrant Gothenburg site is a truly inspiring place to work. Here, the history and future of scientific breakthrough come together. We believe that the diversity of our people is crucial to bringing new discoveries to life.

So, what's next? If this sounds like your next challenge - apply today!

Welcome with your application, but send it to us no later than 15th August, 2022.

For more information about the position please contact Nidhal Selmi, Director of Chemistry - DNA-Encoded & Compound Collection Libraries - iLAB, at nidhal.selmi(at)astrazeneca.com.

Additional information:
Our Gothenburg site: https://www.astrazeneca.com/our-science/gothenburg.html
Life in Gothenburg: https://www.movetogothenburg.com/
About iLAB - Innovation Lab: https://www.astrazeneca.com/r-d/our-technologies/ilab.html

NOTE - Due to our summer vacation period in Sweden during July-August, the screening process may take a bit longer than usual. Thanks for your understanding and we will get back to you as soon as possible when we are back at work.