Senior Research Scientist - Experienced Protein Scientist

Are you truly passionate about the magic that happens in the lab? Could you see yourself applying your protein science knowledge in a successful pharmaceutical company? Would you like to join a team of highly skilled scientists where both your professional and personal skills are valued?
We have an exciting opportunity for you to join us working within a dynamic scientific environment to support drug discovery with a focus on membrane protein targets. The Discovery Biology department within Discovery Sciences is responsible for the generation of novel reagents and assays to support projects in all phases of the drug discovery pipeline. We focus on scientific advances in small molecules, oligonucleotides and other new technologies and drug discovery platforms across our different core disease areas.
Our stunning campus in Gothenburg is one of AstraZeneca’s three strategic science centres. The site is home to over 2,500 employees, from 50 different nationalities. Gothenburg includes the complete range of functions, and as such offers plenty of development opportunities for a wide variety of professionals. Our science teams in Gothenburg collaborate with academic and industry partners in Sweden and globally. And the site itself is designed with collaboration in mind. From the Coffee Lab to exercise areas, we’ve built a series of environments where innovation can happen.

Om tjänsten
Main Duties and Responsibilities
You will be responsible for producing and characterizing recombinant membrane protein complexes primarily for Cryo-EM structure based drug discovery applications. The purified complexes may further be applied for biophysical assays and affinity screening methods. Mutagenesis and pharmacological profiling will be relevant to optimize bioreagents and in support of molecular mode of action studies. Since this position is predominantly lab based, we expect that you have a true passion for practical duties and high quality data and reagent generation.

Dina arbetsuppgifter i huvudsak
We will rely on you to:
• Work in a cross functional setting to deliver high-quality membrane protein reagents to projects
• Deliver expertise in protein expression, purification and characterization with a focus on G-protein coupled receptors (GPCRs)
• Contribute with novel ideas and using discernment and knowledge where appropriate to influence the work of the project
• Maintain an awareness of current developments in the literature and contribute to the continuous improvement process
• Achieve personal as well as company scientific visibility through project contributions, presentations, publications and poster & oral conference presentations

Vem är du?
Essential Requirements
• MSc degree with significant experience from pharmaceutical or biotechnology industry or PhD in Biology, Pharmacology, Biochemistry or other a related discipline
• Expertise in protein science of membrane proteins through a demonstrable knowledge of construct design, molecular biology, protein expression, extraction/solublization, purification, characterization and structure function relationship
• Proven knowledge of a wide range of methods and technologies applied to the expression, purification as well as characterization of membrane proteins, e.g. Eukaryotic expression systems, liquid chromatography, mass spectrometry and biophysical techniques
• Excellent analytical skills, good scientific judgement and communication skills
• Good team working and networking skills with experience of interacting effectively across disciplines and in multi-cultural settings

Desirable Requirements
• Experience of GPCRs and cellular pharmacological profiling
• Experience with non-detergent based formulations for purified membrane proteins
• Experience with structure determination methods in particular Cryo-EM

Om verksamheten
AstraZeneca is an equal opportunity employer. AstraZeneca will consider all qualified applicants for employment without discrimination on grounds of disability, sex or sexual orientation, pregnancy or maternity leave status, race or national or ethnic origin, age, religion or belief, gender identity or re-assignment, marital or civil partnership status or any other characteristic protected by law.

This is a consultant assignment for AstraZeneca in Gothenburg for 1.5 year. During the period of the assignment you will be employed by Poolia.


Additional information
Our Gothenburg site: https://www.astrazeneca.com/our-science/gothenburg.html
Life in Gothenburg: https://www.movetogothenburg.com/
Culture and atmosphere of the site: https://www.linkedin.com/feed/update/urn:li:activity:6496327311678410752/