Senior Research Scientist - Experienced Protein Scientist

Are you truly passionate about the magic that happens in the lab? Could you see yourself applying your protein science knowledge in a successful pharmaceutical company? Would you like to join a team of highly skilled scientists where both your professional and personal skills are valued?

We have an exciting opportunity for you to join us working within a dynamic scientific environment to support drug discovery with a focus on membrane protein targets. The Discovery Biology department within Discovery Sciences is responsible for the generation of novel reagents and assays to support projects in all phases of the drug discovery pipeline. We focus on scientific advances in small molecules, oligonucleotides and other new technologies and drug discovery platforms across our different core disease areas.

Our stunning campus in Gothenburg is one of AstraZeneca’s three strategic science centres. The site is home to over 2,500 employees, from 50 different nationalities. Gothenburg includes the complete range of functions, and as such offers plenty of development opportunities for a wide variety of professionals. Our science teams in Gothenburg collaborate with academic and industry partners in Sweden and globally. And the site itself is designed with collaboration in mind. From the Coffee Lab to exercise areas, we’ve built a series of environments where innovation can happen.


MAIN DUTIES AND RESPONSIBILITIES
YOU WILL BE RESPONSIBLE FOR PRODUCING AND CHARACTERIZING RECOMBINANT MEMBRANE PROTEIN COMPLEXES PRIMARILY FOR CRYO-EM STRUCTURE BASED DRUG DISCOVERY APPLICATIONS. THE PURIFIED COMPLEXES MAY FURTHER BE APPLIED FOR BIOPHYSICAL ASSAYS AND AFFINITY SCREENING METHODS. MUTAGENESIS AND PHARMACOLOGICAL PROFILING WILL BE RELEVANT TO OPTIMIZE BIOREAGENTS AND IN SUPPORT OF MOLECULAR MODE OF ACTION STUDIES. SINCE THIS POSITION IS PREDOMINANTLY LAB BASED, WE EXPECT THAT YOU HAVE A TRUE PASSION FOR PRACTICAL DUTIES AND HIGH QUALITY DATA AND REAGENT GENERATION.

WE WILL RELY ON YOU TO:
• WORK IN A CROSS FUNCTIONAL SETTING TO DELIVER HIGH-QUALITY MEMBRANE PROTEIN REAGENTS TO PROJECTS
• DELIVER EXPERTISE IN PROTEIN EXPRESSION, PURIFICATION AND CHARACTERIZATION WITH A FOCUS ON G-PROTEIN COUPLED RECEPTORS (GPCRS)
• CONTRIBUTE WITH NOVEL IDEAS AND USING DISCERNMENT AND KNOWLEDGE WHERE APPROPRIATE TO INFLUENCE THE WORK OF THE PROJECT
• MAINTAIN AN AWARENESS OF CURRENT DEVELOPMENTS IN THE LITERATURE AND CONTRIBUTE TO THE CONTINUOUS IMPROVEMENT PROCESS
• ACHIEVE PERSONAL AS WELL AS COMPANY SCIENTIFIC VISIBILITY THROUGH PROJECT CONTRIBUTIONS, PRESENTATIONS, PUBLICATIONS AND POSTER &AMP ORAL CONFERENCE PRESENTATIONS

ESSENTIAL REQUIREMENTS
• MSC DEGREE WITH SIGNIFICANT EXPERIENCE FROM PHARMACEUTICAL OR BIOTECHNOLOGY INDUSTRY OR PHD IN BIOLOGY, PHARMACOLOGY, BIOCHEMISTRY OR OTHER A RELATED DISCIPLINE
• EXPERTISE IN PROTEIN SCIENCE OF MEMBRANE PROTEINS THROUGH A DEMONSTRABLE KNOWLEDGE OF CONSTRUCT DESIGN, MOLECULAR BIOLOGY, PROTEIN EXPRESSION, EXTRACTION/SOLUBLIZATION, PURIFICATION, CHARACTERIZATION AND STRUCTURE FUNCTION RELATIONSHIP
• PROVEN KNOWLEDGE OF A WIDE RANGE OF METHODS AND TECHNOLOGIES APPLIED TO THE EXPRESSION, PURIFICATION AS WELL AS CHARACTERIZATION OF MEMBRANE PROTEINS, E.G. EUKARYOTIC EXPRESSION SYSTEMS, LIQUID CHROMATOGRAPHY, MASS SPECTROMETRY AND BIOPHYSICAL TECHNIQUES
• EXCELLENT ANALYTICAL SKILLS, GOOD SCIENTIFIC JUDGEMENT AND COMMUNICATION SKILLS
• GOOD TEAM WORKING AND NETWORKING SKILLS WITH EXPERIENCE OF INTERACTING EFFECTIVELY ACROSS DISCIPLINES AND IN MULTI-CULTURAL SETTINGS

DESIRABLE REQUIREMENTS
• Experience of GPCRs and cellular pharmacological profiling
• Experience with non-detergent based formulations for purified membrane proteins
• Experience with structure determination methods in particular Cryo-EM

 

ABOUT ALTEN
Every employee is equally valuable in the success of ALTEN! We are driven by making people grow and develop, which is why we offer you the opportunity to work with what you are truly passionate about. At ALTEN, we have a broad range of assignments at most of the leading companies in Sweden in several different sectors, to make it possible for your wishes to come true. We offer both national and international opportunities and together with your coaching manager, you build your career path so you constantly are able to develop and achieve your goals and dreams! As a consultant at ALTEN, you will get the genuine team feeling at your assignment but also a wonderful togetherness at ALTEN. Through our different internal networks, such as ALTEN Sports, Women@ALTEN and ALTEN Innovation you will get the opportunity to drive topics and activities that are close to your heart, together with your colleagues. All activities are of course optional. Work life balance is our top priority. We also have a collective agreement and other benefits like Pension, Insurances and Wellness grants.

 

We believe in growing together!