senior research scientist - experienced protein scientist

Job description
We are currently looking for an experienced protein scientist for an exciting consultant assignment at AstraZeneca in Gothenburg.


Are you truly passionate about the magic that happens in the lab? Could you see yourself applying your protein science knowledge in a successful pharmaceutical company? Would you like to join a team of highly skilled scientists where both your professional and personal skills are valued? 

 We have an exciting opportunity for you to join us working within a dynamic scientific environment to support drug discovery with a focus on membrane protein targets. The Discovery Biology department within Discovery Sciences is responsible for the generation of novel reagents and assays to support projects in all phases of the drug discovery pipeline. We focus on scientific advances in small molecules, oligonucleotides and other new technologies and drug discovery platforms across our different core disease areas. 


 Our stunning campus in Gothenburg is one of AstraZeneca’s three strategic science centres. The site is home to over 2,500 employees, from 50 different nationalities. Gothenburg includes the complete range of functions, and as such offers plenty of development opportunities for a wide variety of professionals. Our science teams in Gothenburg collaborate with academic and industry partners in Sweden and globally. And the site itself is designed with collaboration in mind. From the Coffee Lab to exercise areas, we’ve built a series of environments where innovation can happen. 


 Randstad Life Sciences is specialized in competences within Life Science. As a consultant with us, you get a competitive salary, benefits and collective agreements. Your consultant manager is always there for you and ensures that you get varying and developing assignments at different companies, within different industries. At Randstad Life Sciences, your personal development is in focus, and you are offered a large network and many social activities. 

Responsibilities
 You will be responsible for producing and characterizing recombinant membrane protein complexes primarily for Cryo-EM structure based drug discovery applications. The purified complexes may further be applied for biophysical assays and affinity screening methods. Mutagenesis and pharmacological profiling will be relevant to optimize bioreagents and in support of molecular mode of action studies. Since this position is predominantly lab based, we expect that you have a true passion for practical duties and high quality data and reagent generation.
 
 We will rely on you to:
 • Work in a cross functional setting to deliver high-quality membrane protein reagents to projects
 • Deliver expertise in protein expression, purification and characterization with a focus on G-protein coupled receptors (GPCRs)
 • Contribute with novel ideas and using discernment and knowledge where appropriate to influence the work of the project
 • Maintain an awareness of current developments in the literature and contribute to the continuous improvement process
 • Achieve personal as well as company scientific visibility through project contributions, presentations, publications and poster & oral conference presentations 

Qualifications
 Essential Requirements
 • MSc degree with significant experience from pharmaceutical or biotechnology industry or PhD in Biology, Pharmacology, Biochemistry or other a related discipline
 • Expertise in protein science of membrane proteins through a demonstrable knowledge of construct design, molecular biology, protein expression, extraction/solublization, purification, characterization and structure function relationship
 • Proven knowledge of a wide range of methods and technologies applied to the expression, purification as well as characterization of membrane proteins, e.g. Eukaryotic expression systems, liquid chromatography, mass spectrometry and biophysical techniques
 • Excellent analytical skills, good scientific judgement and communication skills
 • Good team working and networking skills with experience of interacting effectively across disciplines and in multi-cultural settings
 
 Desirable Requirements
 • Experience of GPCRs and cellular pharmacological profiling
 • Experience with non-detergent based formulations for purified membrane proteins
 • Experience with structure determination methods in particular Cryo-EM 


For us, it is important that all competence and skills in the labor market are utilized. We welcome all applicants and strive for diversity. 


Additional information
Our Gothenburg site: https://www.astrazeneca.com/our-science/gothenburg.html
Life in Gothenburg: https://www.movetogothenburg.com/
Culture and atmosphere of the site: https://www.linkedin.com/feed/update/urn:li:activity:6496327311678410752/ 

Application
2021-08-19, selection and interviews will be performed ongoing. The position may be filled before the last day of application, therefore, apply as soon as possible. 


For more information, please contact consultant manager Birgitta Nyström at birgitta.nystrom@randstad.se 

About the company
Randstad Life Sciences specializes in the field of science and is part of Randstad, the world leader in recruitment and consulting with operations in 38 countries. With this global network, in combination with our strong local foundation, we can offer a wide range of varied and developing assignments and jobs for you who are a specialist in life science. Our mission is to help you reach your true potential with your career in focus!