Senior Research Scientist – Genome Engineering/Gene Therapy

At AstraZeneca we use scientific excellence as our foundation for driving success in our drug discovery pipeline. We underpin this with strong collaboration, clear direction and a focus on applying cutting-edge research to support drug discovery.

An exciting opportunity is now available to join the Genome Engineering team within Discovery Sciences, which has responsibility for the generation of novel genome editing technologies to support projects in all phases of the drug discovery pipeline. We have a focus on target identification, target validation, disease model generation and the therapeutic use of stem cells. We are seeking a scientist to join our team in Gothenburg Sweden, where the role will focus on the in vivo delivery of CRISPR/cas9 reagents and assessing the genome editing outcome.

About the position
With your knowledge and experience in genome editing you will have the opportunity to apply this to gene therapy projects. The role is focused on conducting laboratory-based activities, applying in vivo knowledge and skills to deliver reagents to mice, collect samples for biomarker assays, and assess editing efficeincy by next generation sequencing. You will drive project delivery and scientific innovation, participate actively in problem solving and work globally with Astrazeneca colleagues and collaborators.

It is essential to have good social and communication skills, be collaborative and a strong team player and be an innovative thinker. Candidates should be able to work independently, take initiative and have a positive, goal oriented and problem-solving attitude. Good organisational, data management and documentation skills are required, and you should be comfortable in presenting your results. English language is required, both spoken and in writing.


Responsibilities
• Perform in vivo genetic editing by delivery of CRISPR/Cas9 reagents to mice
• Collect samples and perform biomarker assays
• Quantify the efficiency of in vivo genome editing
• Analyse data and present results

Your profile
Essential skills for the job:
• You should hold a degree or have significant relevant experience working in with small animals and a molecular biology environment.
• Licensed and proficient in ‘hands on’ in vivo work, delivery of reagents and collection of samples for biomarker assay
• Strong knowledge and experience with core molecular biology techniques
• Expertise with CRISPR based editing and NGS analysis of genome editing outcomes

The following skills are highly desirable but not essential
• Perform routine laboratory assays such as ELISA and possibly develop novel assays


About the organisation
This position is a consultant assignment at AstraZeneca via QRIOS Life Science & Engineering in Göteborg for one year. During this time you will be employed by QRIOS Life Science & Engineering.
QRIOS employs curious experts in IT, Life Science and Engineering. We want to continue to attract the best employees, to continue to support our partners with the important competences you require. We are a recruitment and consulting company that is strongly inspired by those who never stop looking for new solutions. As we say, QRIOS MINDS GO FURTHER

Why AstraZeneca?
Our Gothenburg site is one of AstraZeneca's three strategic R&D centers. With more than 2,400 employees from over than 50 countries, our vibrant Gothenburg site is a truly inspiring place to work. Here, the history and future of scientific breakthrough come together. We believe that the diversity of our people is crucial to bringing new discoveries to life.