Senior Research Scientist – Genome Engineering/Gene Therapy

Job description
Senior Research Scientist – Genome Engineering/Gene Therapy

At AstraZeneca we use scientific excellence as our foundation for driving success in our drug discovery pipeline. We underpin this with strong collaboration, clear direction and a focus on applying cutting-edge research to support drug discovery.

An exciting opportunity is now available to join the Genome Engineering team within Discovery Sciences, which has responsibility for the generation of novel genome editing technologies to support projects in all phases of the drug discovery pipeline. We have a focus on target identification, target validation, disease model generation and the therapeutic use of stem cells. We are seeking a scientist to join our team in Gothenburg Sweden, where the role will focus on the in vivo delivery of CRISPR/cas9 reagents and assessing the genome editing outcome.

Responsibilities
The role
With your knowledge and experience in genome editing you will have the opportunity to apply this to gene therapy projects. The role is focused on conducting laboratory-based activities, applying in vivo knowledge and skills to deliver reagents to mice, collect samples for biomarker assays, and assess editing efficeincy by next generation sequencing. You will drive project delivery and scientific innovation, participate actively in problem solving and work globally with Astrazeneca colleagues and collaborators.

It is essential to have good social and communication skills, be collaborative and a strong team player and be an innovative thinker. Candidates should be able to work independently, take initiative and have a positive, goal oriented and problem-solving attitude. Good organisational, data management and documentation skills are required, and you should be comfortable in presenting your results. English language is required, both spoken and in writing.

Tasks
Perform in vivo genetic editing by delivery of CRISPR/Cas9 reagents to mice
Collect samples and perform biomarker assays
Quantify the efficiency of in vivo genome editing
Analyse data and present results


Qualifications
Essential for the job
Licensed and proficient in ‘hands on’ in vivo work, delivery of reagents and collection of samples for biomarker assay
Strong knowledge and experience with core molecular biology techniques
Expertise with CRISPR based editing and NGS analysis of genome editing outcomes

The following skills are highly desirable but not essential
Perform routine laboratory assays such as ELISA and possibly develop novel assays

Minimum experience
You should hold a degree or have significant relevant experience working in with small animals and a molecular biology environment.


Application
Deadline: 2022-04-07, selection and interviews will be ongoing. The position may be filled before the last day of application, therefore, apply as soon as possible.

For more information:
Please contact Jimmy Wadie jimmy.wadie@randstad.se or Veronika Knudsen veronika.knudsen@randstad.se

About the company
Randstad Life Sciences is specialized in competences within Life Science. As a consultant with us, you get a competitive salary, benefits and collective agreements. Your consultant manager is always there for you and ensures that you get varying and developing assignments at different companies, within different industries. At Randstad Life Sciences, your personal development is in focus, and you are offered a large network and many activities.

Randstad Life Sciences specializes in the field of science and is part of Randstad, the world leader in recruitment and consulting with operations in 38 countries. With this global network, in combination with our strong local foundation, we can offer a wide range of varied and developing assignments and jobs for you who are a specialist in life science. Our mission is to help you reach your true potential with your career in focus!