Senior Research Scientist - Imaging of PROTAC cellular models

Are you a curious scientist with expertise in cellular biology and possess cell imaging skills? Would you like to apply these skills to impact the field of cellular model development in a company that follows the science and turns ideas into life changing medicines for patients worldwide? Then AstraZeneca might be the place for you!

As a Senior Research Scientist in Gothenburg, Sweden, you'll play a pivotal role in channeling our scientific capabilities to make a positive impact on changing patients' lives. As a part of the Discovery Biology Department in the Cellular Biology Team you will be developing bespoke cellular models using state-of-the-art imaging to support screening assays and detailed biological mechanism-of-action studies in support of our PROTAC-centric drug discovery pipeline.

You will work within Discovery Sciences, part of AstraZeneca's BioPharmaceuticals organisation, which focuses on scientific advances in established and emerging medicine formats and drug discovery technologies across therapeutic areas including Respiratory & Inflammation (R&I), Cardiovascular, Renal & Metabolism (CVRM), and Neuroscience.

What you will do:
The successful candidate will take a lead scientific role in applying their cell imaging skills to design, generate, validate and characterize cellular models to progress PROTAC-centric drug discovery. You will provide expertise in qualitative high content imaging of cellular models across a range of imaging platforms, scales of throughput, and cell types.

It is a lab-based position where you will utilize your expertise in cellular model generation through genome engineering and imaging to independently design, develop and validate models for implementation in drug discovery projects, while incorporating the views of others. In addition, you will employ cutting-edge cell biology, imaging, and analysis skills to drive scientific development in the field. The position also includes:

* Design and implementation of work-plans to agreed timelines to meet project objectives, including delivery of more than one agreed area of work in parallel
* Be an effective member of Drug Discovery Project Teams, contributing novel ideas and using judgement and knowledge to influence the work of the project
* Achieve personal scientific visibility through project contributions and internal presentations at departmental or functional meetings; and external scientific visibility through poster and oral conference presentations and authorship on peer-reviewed publications

Essentials for the role:

* PhD in Biology, Pharmacology, Cell Biology or a related discipline or a BSc/MSc degree with significant relevant experience, preferably in the pharmaceutical or biotechnology industry
* Expertise in cellular genome engineering from demonstrable design and tool generation through to validation and functional characterisation
* Expertise in the design, employment and analysis of high-content imaging via light microscopy on a variety of platforms, at various scales and a range of cell types
* Significant experience in the development of scripts for quantitative and qualitative image analysis
* Strong experience in appropriate cellular biology techniques applied to development of physiologically relevant cellular assays (endogenous gene-tagging, gene expression knock-down, transfection methods)

Desirable for the role:

* Expert in the biology of the Ubiquitin-Proteasome System (UPS)
* Experience in the use of AI for high content image analysis
* Good publication records in peer-reviewed journals demonstrating imaging expertise and preferably in the field of UPS biology
* Excellent problem-solving skills, strong delivery focus and communication skills. Effective team worker with experience of interacting effectively across interfaces of discipline, culture, and expertise
* Research experience in R&I, CVRM and/or Neuroscience diseases

Why AstraZeneca in Gothenburg?
At AstraZeneca we work together across global boundaries to make an impact and find answers to challenges. We do this with the upmost integrity even in the most difficult situations because we are committed to doing the right thing. We continuously forge partnerships that help pursue world-class medicines in new ways, combining our people's exceptional skills with those of people from all over the globe.

Our Gothenburg site: https://www.astrazeneca.com/our-science/gothenburg.html
Life in Gothenburg: https://www.movetogothenburg.com/

If this sounds like your next challenge - apply today! We look forward to your application no later than 5th July 2020.

For further details around this position you are welcome to contact the recruiting manager Sam Barichievy, email: Samantha.Barichievy@astrazeneca.com