Senior Research Scientist in Bioinformatics - Cell Therapy

Are you a Bioinformatician with great knowledge of human genetics and cell biology? Do you also feel passionate about working in an environment focused on pre-clinical drug discovery where you can make a difference? If yes, this might be the next challenge for you!

Our Quantitative Biology team in Gothenburg, Sweden is looking for a Bioinformatician/Senior Research Scientist in Bioinformatics to help us evolve our Next Generation Sequencing analytics. Our focus is to improve patient care by providing insights into human biology through facilitating a discovery of new therapeutics. You will play a key role in supporting, driving and developing multi-omics projects.

Our focus also includes supporting the identification of novel drug targets as well as prioritization of targets within our drug discovery portfolio by providing data analysis solutions to high dimensional biological datasets. We encourage you to join us in our journey to develop novel medicines and improve lives of millions of people worldwide.

Feel free to watch our Data Sciences & Quantitative Biology film to get to know the team and our department better: A Life-changing day - Meet our Quantitative Biology team at AstraZeneca

What you'll do:
As a Senior Research Scientist in Bioinformatics you will;

* Collaborate optimally with experimentalists and bioinformaticians across the company to develop novel data science approaches to cell therapy, target identification and validation.
* Impact, prototype and build analytical pipelines for identifying novel drug targets as well as prioritizing and triaging existing portfolio of targets using computational expertise and domain knowledge.
* Ensure and organize effective communication between experimental scientists and computational biologists.
* Improve the company's ability to prioritize target selection and portfolio projects based on probability of technical success.
* Ensure scientific excellence in software, processes and results as well and be efficient and well documented.

Essential in the role:
We believe you are a motivated and skilled Bioinformatician with a consistent track record of delivering analytical solutions for business or academic needs. Your ability to convert details into comprehensive information by collaborating with colleagues, as well as customers will be of great importance.

We expect you to have:

* PhD or similar research experience in Bioinformatics, Genetics, Computer Science, or alternatively a Biology or Medicine degree with a strong emphasis on data analysis.
* Knowledge of human genetics, cell biology and/or a solid understanding of a disease area
* Experience with algorithms, approaches and databases for pathway identification and analysis (IPA, MetaBase, Reactome, etc).
* Shown experience in data analysis, management and visualization several of the following core areas: RNA or DNA based omics (RNA-seq, ChIP-seq, ATAC-seq, WGBS), statistical genetics, multivariate and/or high dimensional omics integration, single-cell technologies, epigenomics, metagenomics.
* Fluency in R, Bioconductor, RMarkdown and related tools.
* Proficiency in working in a Linux environment, experience with shell scripting and standard command line tools.

Desirable in the role:

* Experience in either Python (Pandas and NumPy stack) or a lower level programming language (C++, Rust, Java, etc.).
* An understanding of in vivo / in vitro model systems, as well as modern approaches to identification and validation of drug targets; an understanding of CRISPR technology.
* Experience with working in an environment focused on pre-clinical drug discovery.
* Familiarity with git, conda and tools for reproducible research such as Snakemake or Nextflow.

Why AstraZeneca in Gothenburg?
With more than 2,800 employees from over 70 countries, our vibrant Gothenburg site is a truly inspiring place to work. Here, the history and future of scientific breakthroughs come together. We believe that the diversity of our people is crucial to bringing new discoveries to life.

If this sounds like the job and place for you to make a change - apply today and come join our exciting journey! Welcome with your application no later than 12th September, 2023.

For more information about the position please contact Petr Volkov, Director - Quantitative Biology SE, at +46 31 776 14 78 or petr.volkov(at)astrazeneca.com.

Additional information:
Our Gothenburg site: https://www.astrazeneca.com/our-science/gothenburg.html
Life in Gothenburg: https://www.movetogothenburg.com/
This is our Discovery Sciences community: https://www.youtube.com/watch?v=pSu2Z7wpC_w