Senior Research Scientist in Translational Genomics

Searching a Senior Research Scientist in Translational Genomics to AstraZeneca for 1-year-contract assignment

Translational Genomics at AstraZeneca in Gothenburg, Sweden, have an exciting opportunity and is seeking a Senior Research Scientist to be part of the Transgenic Models team. The position is available immediately for a highly skilled and motivated cell and molecular biologist with extensive experience and state-of-the-art knowledge in transgenic science & technology. If this sounds like the challenge for you, apply today!

We are looking for an expert in the area of murine transgenesis and its application in transgenic animal model generation. This person will devise, champion and develop scientific areas aligned with project needs and be an authority in the area of molecular biology and precise genome editing - to lead this from a lab-based perspective and to make significant contributions to the practical delivery of AstraZeneca project goals.

You will provide disciplinary scientific leadership and represent the department at internal interdisciplinary meetings in addition to external meetings and to publish novel science in high impact journals. Along with this, you will propose experimental strategies, troubleshoot problems and make significant contributions to the practical delivery of projects in compliance with AstraZeneca corporate responsibility policies and relevant safety standards. We see that you have good social and communication skills, are collaborative and a strong team player. You should also be able to work independently and have a positive, goal oriented and problem-solving attitude. Excellent English is required, both spoken and written, and good organizational skills are essential.

The following skills are highly desirable:

* Molecular and cell biology expertise with an emphasis on construct design and generation via DNA cloning
* Experience of working with mouse embryonic stem cells
* Working knowledge of the latest precise genome engineering tools both in vitro and in vivo

The following skills would be an advantage:

* Experience of phenotypic characterization of transgenic mouse models related to metabolic and behavioural phenotyping platforms.

Minimum experience

* You should have a Ph.D. or first degree and corresponding experience in a relevant scientific discipline. Experience in the generation of transgenic mouse models would be an advantage.

Generic component of SRS role descriptor
Accountabilities

* To design genome editing-based strategies and tools required to generate in vivo and in vitro reagents to create disease models
* To perform genetic screens in vitro and in vivo using genome editing tools
* To perform confirmation assays of genetic manipulation and functional validation of engineered animals
* To perform in vivo target validation studies in early projects

What to do now? Apply with your CV or contact me if you have any questions about the role.