Senior Research Scientist - Oligonucleotide Chemistry

Are you a Senior Research Scientist with a passion for and expertise of synthetic chemistry related to oligonucleotides? Do you want to join a growing team where you have the opportunity to further exploit our drug discovery platforms? If yes, this might be the opening for you!

We are looking for two Senior Research Scientists to join our great Oligonucleotide Chemistry team within the Oligonucleotide Discovery Department in Gothenburg, Sweden. You will apply expert knowledge and synthesis skills in the Oligonucleotide field to expand the use of oligonucleotides, and molecular conjugates thereof, in the treatment of diseases across therapy areas within AstraZeneca. In doing so you demonstrate a passion for driving scientific questions, combined with strong team working ethics, to drug discovery projects.

The Oligo Chemistry team is working in close collaboration with scientists in other functions with a focus on the goal to design and develop the oligo therapeutics of the future. We offer a highly rewarding scientific environment and with an expectation to publish new findings.

We continually push the boundaries of science to deliver medicines that treat diseases across our main therapy areas. Through our integration with Alexion, this now includes expanding the limits of scientific research to better understand rare diseases and to discover new life-changing treatments for them.

What you will do:
This role is a synthesis specialist role in oligonucleotide chemistry with a focus on developing oligonucleotide drugs and thereby supporting the AstraZeneca pipeline. You should be able to apply purification and analytical sciences, propose experimental strategies, troubleshoot problems and make a significant contribution to the practical delivery of project compounds. As well as synthesize and purify high quality building blocks and compounds by applying cutting-edge technologies and methodologies to support project progression from according to agreed timelines.

The Senior Research Scientist work alongside other chemists in the team to support project priorities but should also be comfortable in supervising more junior scientists. The role includes development of new building blocks and linkers as well as setting up new techniques. You will support oligonucleotide projects to ensure high scientific standards and quality of compounds to meet project objectives and support publication opportunities in the field of oligonucleotides.

Essential in the role:

* Candidate should have a PhD in Organic Chemistry, post-doc is a plus.
* Detailed knowledge of synthetic chemistry related to oligonucleotides, oligo building blocks and/or synthesis of advanced organic molecules. Knowledge in the area of oligonucleotide therapeutics, design and data analysis is a plus.
* Ability to design and execute experiments autonomously.
* Evidence of experimental impact by either peer-reviewed publications or external presentations.

We also believe that our new colleagues are individuals who thinks outside the box and find innovative scientific approaches. You hold enthusiasm and curiosity towards scientific questions and have a scientifically critical mindset capable of receiving and analyzing input from multiple disciplines. You can work in an independent and goal-oriented way, but you also enjoy team work and collaboration with ability to communicate in a global setting with cross-functional groups.

Why AstraZeneca?
Join the team unlocking the power of what science can do. We are working towards treating, preventing, modifying and even curing some of the world's most complex diseases. Here we have the potential to grow our pipeline and positively impact the lives of billions of patients around the world. Thrive in a place where the brightest and most curious minds seamlessly come together in our inclusive environment.

So, what's next? If you want to join our Oligo journey - welcome to apply today!

We look forward to get to know you better. Send in your application as soon as possible, but no later than 27th February, 2022.

For more information about the position please contact Anders Dahlén at +46 31 706 4842 or anders.dahlen@astrazeneca.com

Additional information:
Our Gothenburg site: https://www.astrazeneca.com/our-science/gothenburg.html
Life in Gothenburg: https://www.movetogothenburg.com/
Make a move to Global Gothenburg: https://www.youtube.com/watch?v=c-Iqbb4aw38
About BioPharmaceuticals R&D: https://www.astrazeneca.com/r-d.html