Senior Research Scientist - Precise Genome Editing

At AstraZeneca we use scientific excellence as our foundation for driving success in our drug discovery pipeline. We underpin this with strong collaboration, clear direction and a focus on applying cutting-edge research to support drug discovery. Welcome to join us and our great place to work!

We are seeking a motivated and skilled Senior Research Scientist to join our Precise Genome Editing team within Discovery Sciences. The position will be based in Gothenburg, Sweden and the scientist in this role will focus on culturing, genetically engineering and differentiating stem cells for cellular model development and their potential use as therapeutics.

This exciting opportunity as Senior Research Scientist in Precise Genome Editing includes responsibility for the generation of novel genome editing technologies to support projects in all phases of the drug discovery pipeline. We have a focus on target identification, target validation, disease model generation and the therapeutic use of stem cells.

The role

Leveraging your strong knowledge and experience in genome editing, you will have the opportunity to generate cutting edge technologies and innovative approaches to manipulate cellular and mouse models for Immuno Oncology studies. This includes design of genome editing strategies and implement them using techniques including CRISPR/Cas9. The role is focused on conducting laboratory-based activities, applying your knowledge and skills to drive project delivery and scientific innovation, participating actively in problem solving and working globally with AstraZeneca colleagues and collaborators.

We believe that the successful candidate has good social and communication skills, is an innovative thinker and enjoys working collaborative as a strong team player. You should be able to work independently, take own initiatives and have a positive, goal oriented and problem-solving attitude. Good organisational, data management and documentation skills are required, and you should be comfortable in presenting your results. English language is required, both spoken and in writing.

Tasks in the role:

* To design genome editing-based strategies and tools required to generate in vitro and in vivo models
* To develop delivery tools to improve the efficiency of genome editing
* To perform confirmation of genetic manipulation and functional validation of engineered models
* To develop novel engineering tools based on CRISPR/Cas9, base/prime editor

The following skills are highly desirable but not essential:

* Molecular biology expertise and manipulation of cell lines and/or mouse embryonic stem cells
* Generation and use of viral vectors (lentivirus, AAV, Adenovirus) for in vitro and in vivo genetic engineering
* Certified experience of work with mouse models (Felasa B and equivalent)
* In silico design and analysis of genetic perturbation by genome editing
* Expertise with NGS and/or genotyping and phenotyping tools to validate genetic perturbations

Minimum requirements

* You should hold a Ph.D. in Molecular Biology, Cellular Biology or a related degree or have significant relevant experience working in a precise genome editing/molecular biology environment.

We look forward to your application no later than the 2nd March, 2020.

More information
For more information about the position please contact: Marcello Maresca +46 (0) 70 631 58 40 or marcello.maresca(at)astrazeneca.com