Senior Research Scientist - Precise Genome Editing/Gene Therapy

Are you a curious scientist, motivated by challenging the boundaries of science that would like to contribute to our strategy of growth through Innovation? Do you have expertise in genome editing and have a passion to work in the lab? This might be the position for you!

We have an exciting opportunity to join the Precise Genome Editing team within Discovery Sciences, which has responsibility for the generation of novel genome editing technologies to support projects in all phases of the drug discovery pipeline. We have a focus on target identification, target validation, disease model generation and the therapeutic use of stem cells.

We are seeking a Senior Research Scientist to join our team at our dynamic R&D site at AstraZeneca in Gothenburg, Sweden. The role will focus on culturing, genetically engineering and differentiating stem cells for cellular model development and their potential use as therapeutics.

What you'll do:
Leveraging your strong knowledge and experience in genome editing you will have the opportunity apply your knowledge to gene therapy projects. This includes design of genome editing strategies, implement them using techniques including CRISPR/Cas9 and validate the results. The role is focused on conducting laboratory-based activities, applying your knowledge and skills to drive project delivery and scientific innovation, participating actively in problem solving and working globally with Astrazeneca colleagues and collaborators.

The job includes:

* To design and develop genome editing-based strategies and tools required to generate in vitro and in vivo models
* To implement delivery tools to improve the efficiency of genome editing
* To perform confirmation of genetic manipulation and functional validation of engineered models
* To develop novel engineering tools based on CRISPR/Cas9, base/prime editors

We also believe that the successful candidate has good social and communication skills, is collaborative and a strong team player. You should be able to work independently, take own initiatives, be an innovative thinker and have a positive, results oriented and problem-solving attitude. Good organisational, data management and documentation skills are required, and you should be comfortable in presenting your results. English language is required, both spoken and in writing.

Essentials in the role:

* Strong knowledge and hands on experience with genome editing tools (including base or prime editors)
* Ph.D. in Molecular Biology, Cellular Biology or a related degree or have significant relevant experience working in a precise genome editing/molecular biology environment.
* Expertise with CRISPR based manipulation of cell lines and/or stem cells
* Expertise with NGS analysis of genome editing outcomes (Amplicon Seq, Guide-Seq, CIRCLE-Seq, Discovery-Seq)

Desirable in the role:

* Basic programming skills with the ability to use and develop in silico genetic analysis tool

Why AstraZeneca?
When we see an opportunity for change, we seize it and make it happen, because any opportunity can be the start of something big. Delivering life-changing medicines is about being entrepreneurial - finding those moments and recognizing their potential. Join us on our journey in finding new ways to work, pioneering cutting edge methods and bringing unexpected teams together!

Does this sound like your next challenge? We look forward to your application no later than 21st June.

If you would like to know more about the position, the team or working at AstraZeneca, please reach out to hiring manager Marcello Maresca at +46 (0) 70 631 58 40.