Senior Research Scientist – Protein Expression

At AstraZeneca we use scientific excellence as the foundation to drive success of our drug discovery pipeline. Such excellence stems from strong collaboration, clear direction and a focus on applying cutting-edge research to support drug discovery.

Om tjänsten
An opportunity is now available for a highly motivated Scientist/Senior Scientist to join the Protein Expression Team within Discovery Biology, Discovery Sciences, BioPharmaceuticals R&D in Gothenburg, Sweden. Leading from the bench, you will apply proven skills in molecular biology, recombinant protein expression, a passion for investigating scientific questions, combined with strong team working ethics, to drug discovery projects. You will join our team whose remit is to support drug discovery projects globally with delivery of impactful recombinant protein reagents used for disease target identification and validation right through to clinical candidate evaluation.

As part of a team within the Discovery Sciences organisation, you will be working within a vibrant scientific environment to support drug discovery. We push scientific advances in small molecules, oligonucleotides as well as other emerging technologies, always with a view to providing medicines to improve patient care. The Discovery Biology Department of Discovery Sciences is responsible for the generation of novel reagents and assays to support projects in the drug discovery pipeline from target discovery all the way to clinical candidate.

Dina arbetsuppgifter i huvudsak
This is a lab-based role, generating bespoke protein reagents to support projects in all phases of the discovery process. The role involves application of leading molecular biology techniques to design expression constructs, make DNA constructs for protein expression, producing recombinant proteins that impact projects, as well as troubleshooting. In addition, you will be required to make a significant contribution to the development and application of novel science to advance our capabilities in the production of molecular biology tools used in early drug discovery.

Vem är du?
Essential Requirements
• Master or Ph. D in Molecular Biology, Biotechnology, Cell Biology, Biochemistry or a related discipline, or 3 years of relevant working experience within Biotechnology
• Substantial expertise in cell culture for recombinant protein expression in a variety of eukaryotic cell types, at scales from 1ml to 20L
• Excellent communication skills and an ability to operate effectively in a multi-disciplinary research environment
• Independent analysis and evaluation of complex data and delivery of data to agreed timelines
• Proven ability in providing technical leadership and guidance to others
• Maintain an awareness of relevant scientific and technical advances to help identify opportunities for capability development

Desirable Requirements
• Experience in design of DNA construct for recombinant protein expression is highly desirable
• Experience in use of automation equipment such as liquid handling platforms is desirable
• Experience in expression of recombinant expressed proteins in baculovirus-infected insect cells
• Good understanding of drug discovery and how to contribute with scientific expertise within own area of expertise to drive project progression
• Excellent problem-solving skills, not limited to own area of expertise
• Clear and firm decision-making skills, coupled with tenacity to see decisions through, even in situations of ambiguity

Om verksamheten
At AstraZeneca you will have the ability to make a more meaningful impact to patients’ lives around the globe, be empowered to be innovative and creative where difference is valued and build a long-term career by unlocking opportunities for lifelong learning.