Senior Research Scientist - Protein Expression Team

At AstraZeneca we use scientific excellence as the foundation to drive success of our drug discovery pipeline. Such excellence stems from strong collaboration, clear direction and a focus on applying cutting-edge research to support drug discovery. Right now, we have an opportunity available for a highly motivated Senior Research Scientist to join the Protein Expression Team within Discovery Biology, Discovery Sciences, BioPharmaceuticals R&D in Gothenburg, Sweden. Is this your next challenge?

Leading from the bench, you will apply proven skills in molecular biology, recombinant protein expression, a passion for investigating scientific questions, combined with strong team working ethics, to drug discovery projects. You will join our team whose remit is to support drug discovery projects globally with delivery of impactful recombinant protein reagents used for disease target identification and validation right through to clinical candidate evaluation.

As part of a team within the Discovery Sciences organisation, you will be working within a vibrant scientific environment to support drug discovery. We push scientific advances in small molecules, oligonucleotides as well as other emerging technologies, always with a view to providing medicines to improve patient care. The Discovery Biology Department of Discovery Sciences is responsible for the generation of novel reagents and assays to support projects in the drug discovery pipeline from target discovery all the way to clinical candidate.

Main Duties & Responsibilities

This is a lab-based role, generating bespoke protein reagents to support projects in all phases of the discovery process. The role involves application of leading molecular biology techniques to design expression constructs, make DNA constructs for protein expression, producing recombinant proteins that impact projects, as well as troubleshooting. In addition, you will be required to make a significant contribution to the development and application of novel science to advance our capabilities in the production of molecular biology tools used in early drug discovery.

Essential Requirements

* Ph. D in Molecular Biology, Biotechnology, Cell Biology, Biochemistry or a related discipline, or 5 years of relevant working experience within Biotechnology
* Substantial expertise in molecular biology using a variety of techniques (Golden Gate, Gibson assembly or similar techniques)
* Experience in design of DNA constructs for recombinant protein production is essential
* Excellent communication skills and an ability to operate effectively in a multi-disciplinary research environment
* Independent analysis and evaluation of complex data and delivery of data to agreed timelines
* Proven ability in providing technical leadership and guidance to others
* Maintain an awareness of relevant scientific and technical advances to help identify opportunities for capability development

Desirable Requirements

* Experience in design of DNA constructs for other applications such as cell line generation for assay is highly desirable
* Experience in use of automation equipment such as liquid handling platforms is desirable
* Experience in cell culture and recombinant protein expression is desirable
* Good understanding of drug discovery and how to contribute with scientific expertise within own area of expertise to drive project progression
* Scientific visibility and leadership through project contributions, internal presentations and external publications
* Excellent problem-solving skills, not limited to own area of expertise
* Clear and firm decision-making skills, coupled with tenacity to see decisions through, even in situations of ambiguity
* Track-record in publishing scientific manuscripts in peer-reviewed journals, and presenting at external conferences

Apply today and come join AstraZeneca and our great place to work!

We look forward to your application no later than the 2nd March, 2020.

More information
For further details around this position you are welcome to contact the recruiting manager Robert Roth (phone +46725826411; email: ).

Additional information
Our Gothenburg site: https://www.astrazeneca.com/our-science/gothenburg.html
Life in Gothenburg: https://www.movetogothenburg.com/