Senior Research Scientist to Astra Zeneca

AstraZeneca is a major international healthcare business engaged in the research, development, manufacture and marketing of prescription pharmaceuticals and the supply of healthcare services. AstraZeneca is proud to offer a unique workplace culture that inspires innovation and collaboration. Co-workers are empowered to express diverse perspectives - and are made to feel valued, energized and rewarded for their ideas and creativity

The Arena

We are looking for an innovative and highly motivated scientist to join our Translational Biomarker Team within the Translational Science Department in the CardioVascular & Metabolic Diseases Medicine Unit (CVMD). You will be part of a creative and flexible team that investigates novel therapies for heart failure, diabetes, non-alcoholic steatohepatitis (NASH) and, chronic kidney disease.

Translational Sciences drives human target identification, patient segmentation and biomarker development based on understanding of human diseases and access to human patient derived cells and tissue samples. Critical is the development of a biomarker strategy, which supports all our projects with a set of appropriate biomarkers to provide an integrated set of data around the compound and target throughout all phases in discovery and development.

Tasks and responsibilities / The role

The successful candidate will be lab based and will contribute for building the biomarker strategy in the CVMD projects. This will involve defining necessary procedures, developing analytical methods using ligand binding techniques (e.g. ELISA, IHC), and / or mass spectrometry based approaches, implementation of the methods to support human target validation, and patient segmentation.

The Senior Scientist is responsible for delivering high quality biomarker data to support CVMD project portfolio. He/she develops methodology for quantification of biomarkers in plasma or other matrices using state of the art analytical techniques and reports methodology, biomarker data and evaluation to the project team.

The role requires interactive, effective communication providing clear data and interpretation to projects and contribution to the TS scientific strategy. The role requires making judgements about complex scientific information sets, developing innovative solutions and applying comprehensive cross-functional understanding.

Requirements

Expertise in range of technical skills, specifically immunoassay/ELISA platforms (MSD, Gyros, Luminex etc), as well as immunohistochemistry, and in situ hybridisation
Experience in mass spectrometry for analysis of biomarkers and other automated processing and analysis equipment would be advantageous
Develop and set up bioanalytical methods for quantification of biomarkers for the CVMD projects.
Perform problem solving studies by identification of issues and where necessary designing experiments to overcome problems
Identify new approaches and technologies that would improve our ability to support projects
Maintain awareness of relevant areas of research, drug discover/development technologies and regulatory requirements through reading scientific literature and guidelines
Plan and report all work to appropriate standards (Good Laboratory Standard, GLS) and keep project teams appraised of findings
Excellent English communication skills, both verbal and written

Minimum experience

Suitable candidates should have a Ph.D in a relevant scientific discipline.

Preferred experience/requirements.

Strong practical experience in assay development, enzyme kinetics, and biomarker analysis using a variety of platforms
Significant experience in development of biomarker immunoassay methods
Experience in various mass spectrometry instrumentation and liquid chromatography separation techniques
Experience in biology of cardiovascular and metabolic diseases
Track record of working collaboratively in project teams to ensure timely delivery of project goals.
Passion for delivering and promoting excellence in science.

Please apply by sending your CV and application as soon as possible to Experis. We select applicants continuously. If you have any questions regarding the position please contact Linda Holmberg at . Welcome with your application!