Senior Research Scientist - Translational Genomics

Translational Genomics at AstraZeneca in Gothenburg, Sweden, have an exciting opportunity and is seeking a Senior Research Scientist to be part of the Transgenic Models team. The position is available immediately for a highly skilled and motivated cell and molecular biologist/rodent in vivo physiologist with extensive experience and state-of-the-art knowledge in transgenic science & technology. If this sounds like the challenge for you, apply today!

Om tjänsten
We are looking for an expert in the area of murine transgenesis and its application in both transgenic animal model generation and in vivo phenotyping. This person will devise, champion and develop scientific areas aligned with project needs and be an authority in the area of molecular biology, in vivo science and precise genome editing - to lead this from a lab-based perspective and to make significant contributions to the practical delivery of AstraZeneca project goals.


Dina arbetsuppgifter i huvudsak
You will provide disciplinary scientific leadership and represent the department at internal interdisciplinary meetings in addition to external meetings and to publish novel science in high impact journals. Along with this, you will propose experimental strategies, troubleshoot problems and make significant contributions to the practical delivery of projects in compliance with AstraZeneca corporate responsibility policies and relevant safety standards.


Vem är du?
We see that you have good social and communication skills, are collaborative and a strong team player. You should also be able to work independently and have a positive, goal oriented and problem-solving attitude. Excellent English is required, both spoken and written, and good organizational skills are essential.

The following skills are highly desirable:
• Molecular biology expertise and experience of working with mouse embryonic stem cells.
• Working knowledge of the latest precise genome engineering tools both in vitro and in vivo.
• Expertise in the generation and phenotypic characterization of transgenic animal models

The following skills would be an advantage:
• Experience in metabolic phenotyping platforms and analysis of metabolic function in mouse models e.g. performing indirect calorimetry and intraperitoneal glucose tolerance tests (IPGTT) to diagnose metabolic function in genetically-engineered mice.
• Experience of murine behavioural phenotyping
• Experience of preclinical mouse models for therapeutic gene editing delivery and efficacy approaches.

Minimum experience
• You should have a Ph.D. degree or corresponding experience in a relevant scientific discipline with experience in drug discovery or, alternatively, a first degree and significant relevant experience in drug discovery.

Generic component of SRS role descriptor
Accountabilities
• To design genome editing-based strategies and tools required to generate in vivo and in vitro reagents to create disease models
• To perform genetic screens in vitro and in vivo using genome editing tools
• To perform confirmation assays of genetic manipulation and functional validation of engineered animals
• To perform in vivo target validation studies in early projects

Om verksamheten
AstraZeneca is an equal opportunity employer. AstraZeneca will consider all qualified applicants for employment without discrimination on grounds of disability, sex or sexual orientation, pregnancy or maternity leave status, race or national or ethnic origin, age, religion or belief, gender identity or re-assignment, marital or civil partnership status or any other characteristic protected by law.

This is a consultant assignment at AstraZeneca for a minimum of one year and with possibilities of extension. During the period of the assignment you will be employed by Poolia.