Senior Research Scientist - Translational Genomics, AstraZeneca

Job description
Translational Genomics at AstraZeneca in Gothenburg, Sweden, have an exciting opportunity and is seeking a Senior Research Scientist to be part of the Transgenic Models team. The position is available immediately for a highly skilled and motivated cell and molecular biologist/rodent in vivo physiologist with extensive experience and state-of-the-art knowledge in transgenic science & technology. If this sounds like the challenge for you, apply today!

Responsibilities
We are looking for an expert in the area of murine transgenesis and its application in both transgenic animal model generation and in vivo phenotyping. This person will devise, champion and develop scientific areas aligned with project needs and be an authority in the area of molecular biology, in vivo science and precise genome editing - to lead this from a lab-based perspective and to make significant contributions to the practical delivery of AstraZeneca project goals. This is a consulting position at AstraZeneca in Gothenburg.

You will provide disciplinary scientific leadership and represent the department at internal interdisciplinary meetings in addition to external meetings and to publish novel science in high impact journals. Along with this, you will propose experimental strategies, troubleshoot problems and make significant contributions to the practical delivery of projects in compliance with AstraZeneca corporate responsibility policies and relevant safety standards.

We see that you have good social and communication skills, are collaborative and a strong team player. You should also be able to work independently and have a positive, goal oriented and problem-solving attitude. Excellent English is required, both spoken and written, and good organizational skills are essential.

Qualifications
The following skills are highly desirable:
Molecular biology expertise and experience of working with mouse embryonic stem cells.
Working knowledge of the latest precise genome engineering tools both in vitro and in vivo.
Expertise in the generation and phenotypic characterization of transgenic animal models.

The following skills would be an advantage:
Experience in metabolic phenotyping platforms and analysis of metabolic function in mouse models e.g. performing indirect calorimetry and intraperitoneal glucose tolerance tests (IPGTT) to diagnose metabolic function in genetically-engineered mice.
Experience of murine behavioural phenotyping.
Experience of preclinical mouse models for therapeutic gene editing delivery and efficacy approaches.

Minimum experience:
You should have a Ph.D. degree or corresponding experience in a relevant scientific discipline with experience in drug discovery or, alternatively, a first degree and significant relevant experience in drug discovery.

Generic component of SRS role descriptor
Accountabilities
To design genome editing-based strategies and tools required to generate in vivo and in vitro reagents to create disease models.
To perform genetic screens in vitro and in vivo using genome editing tools.
To perform confirmation assays of genetic manipulation and functional validation of engineered animals.
To perform in vivo target validation studies in early projects.

For us, it is important that all competence and skills in the labor market are utilized. We welcome all applicants and strive for diversity.

Application
2021-06-10, selection and interviews will be ongoing. The position may be filled before the last day of application, therefore, apply as soon as possible.


For more information: Galia Nyström galia.nystrom@randstad.se

About the company
Randstad Life Sciences is specialized in competences within Life Science. As a consultant with us, you get a competitive salary, benefits and collective agreements. Your consultant manager is always there for you and ensures that you get varying and developing assignments at different companies, within different industries. At Randstad Life Sciences, your personal development is in focus, and you are offered a large network and many social activities.

Randstad Life Sciences is part of Randstad, the world leader in recruitment and consulting with operations in 38 countries. With this global network, in combination with our strong local foundation, we can offer a wide range of varied and developing assignments and jobs for you who are a specialist in life science. Our mission is to help you reach your true potential with your career in focus!