Senior Scientist - ADME therapeutic oligonucleotides

Are you an in vitro DMPK scientist with expertise in Absorption, Distribution, Metabolism and Elimination (ADME) of oligonucleotides? Would you like to apply your expertise in a company that is accelerating innovative science and turn ideas into life changing medicines? Join us to discover future treatment of Cardiovascular, Renal and Metabolic diseases!

Working at AstraZeneca means being entrepreneurial, thinking big and working together to make the impossible a reality. We are committed to the development of next generation innovative medicines and are currently building a cross-functional oligonucleotide capability for the treatment of diseases across therapy areas.

As part of the expansion within the therapeutic oligonucleotides area, we are now recruiting a senior in vitro ADME scientist to join the Drug, Metabolism and Pharmacokinetics (DMPK) department within Research and Early Development Cardiovascular, Renal and Metabolism (CVRM). The position is placed at AstraZeneca's dynamic R&D site in Gothenburg, Sweden.

CVRM is one of the three main therapeutic research areas within AstraZeneca which deliver candidate drugs into clinical development. CVRM DMPK interacts with other functions in supporting CVRM projects along the value chain, from target selection all the way to launch and life cycle management. We hope that you will be the one to help us increase our capability regarding ADME and Bioanalysis of oligonucleotide therapeutics!

What you'll do

As a senior in vitro ADME scientist you will be part of a team at the forefront of DMPK science working with all aspects of drug disposition, from whole body, tissues to subcellular drug handling, and relating exposure to drug effects. We are accountable for the breadth of the CVRM drug portfolio, and this role will enhance our team in the area of oligonucleotide therapeutics. You will have the opportunity to contribute to the discovery of new life changing medicines for patients and demonstrate and witness what science can do. Responsibilities include:

* Be responsible for designing, conducting, interpret and reporting of in vitro ADME studies for nucleotide drugs. You will apply state of the art in-vitro DMPK science, including the use of 3D-cell cultures, across drug discovery and development to support design and project progression.
* Provide scientific leadership by leading and driving collaborations with key academic centers and by presenting work through lectures and publications in top-tier scientific journals.
* Identify improvements in technologies that can be successfully applied to a highly competitive drug discovery or development paradigm that contributes to achievement of short and long term business goals and influences strategic direction.
* May be part of cross-functional work-streams and lead the development and implementation of DMPK scientific strategies, and act as a catalyst for scientific debate within the AstraZeneca science community

Essential for the role

* PhD or equivalent in relevant discipline, and at least three years of experience relevant to the position
* Background in Pharmacy, Biology, Biochemistry, Medical Biosciences or similar relevant discipline.
* Versatile in in vitro laboratory skills (e.g. handling and culturing of primary human hepatocytes and other human cells and tissues, molecular biology methods and image analysis, enzyme and transporter kinetic studies)
* Broad knowledge about ADME processes and relevant in vitro models of drug disposition. Track record in development, characterization and application of translatable in vitro models beyond small molecule drugs
* Excellent understanding of design and interpretation of in-vitro studies with oligonucleotide drugs is desired, experience from metabolic disease in vitro models is a strong advantage
* Knowledge in omics technologies and bioinformatics
* Experience in bioanalytical techniques, e.g. LC-MS
* Scientific leadership, evidenced by a publication track record
* Excellent interpersonal skills and good communication skills in English, both verbal and in writing
* Strong ability to engage and collaborate across boundaries with a problem-solving attitude and focus on delivery.
* Experience from industry environment is a plus, but not mandatory.
* Expertise in automation equipment and automated processing would be advantageous

So, what's next?

Are you already imagining yourself joining our team? Great, because we can't wait to hear from you!

For more information about the position please contact hiring manager Constanze Hilgendorf , +46-31-776 10 00

Welcome with your application no later than August 31, 2020

Where can I find out more?

Our AZ Gothenburg site: link

Life in Gothenburg: link

Culture and atmosphere of the Gothenburg site: link

Meet Hasse, Chemist at AstraZeneca Gothenburg: link