Senior Scientist, Biomarker Discovery and Development

Biomarker team in the department of Translational Science and Experimental Medicine (TS&EM)

Hays Life Sciences is now looking to recruit a Senior Scientist, Biomarker Discovery and Development to join the Biomarker team for a 1-year contract assignment at AstraZeneca in Gothenburg.

Do you have expertise in Biomarker Discovery and Development in Cardiovascular, Metabolic and Renal Diseases? Would you like to apply your expertise at a company that are following the science and turn ideas into life changing medicines? If this matches your ambition and skills, then you might be the one we are looking for!

We are now recruiting a Senior Scientist, Biomarker Discovery and Development to join the Biomarker team in the department of Translational Science and Experimental Medicine (TS&EM) within Early Cardiovascular Renal and Metabolic Diseases (CVRM) therapeutic area at AstraZeneca in Gothenburg, Sweden.

Early Cardiovascular, Renal and Metabolism (CVRM) is accountable for the discovery and development (up to phase II) of new medicines within three main strategic areas - cardiovascular/heart failure, metabolism (diabetes and NASH) and chronic kidney disease. The Translational Sciences and Experimental Medicine (TS&EM) Department within Early CVRM has the remit to bridge early and late drug development by providing: i) target validation in humans; ii) biomarker strategy (target engagement & proof of mechanism biomarkers); iii) precision medicine strategies; and iv) human data-driven novel target identification.

Biomarker team delivers high-quality biomarker assays for assessment of target engagement and proof-of-mechanism as well as for precision medicine hypothesis generation from in vitro and in vivo models up to patients.

What you'll do
As a Biomarker Scientist, you will be a key member in the Biomarker Discovery and Development team and play a key role from preclinical to clinical biomarker delivery for progressing projects and science. This role will be primarily lab based and contribute to building the biomarker strategy i.e., driving biomarker discovery for identification of target-related biomarkers and for precision medicine hypothesis generation. You will be responsible for delivering high quality and robust biomarker data package to support project progression across the CVRM project portfolio. This involves implementation of novel biomarker methods e.g. mass spectrometry-based approaches using state of the art analytical techniques, biomarker analysis, reporting biomarker data and evaluation to the project teams
Collaboration is critical for successful delivery of drug projects and you will work closely with scientists/teams from a wide range of different functions within AstraZeneca. In this role, you will have the opportunity to try novel techniques and ideas for identification of new biomarkers.

Essential for the role

* PhD or equivalent education in analytical chemistry or related scientific discipline
* A solid background in the field of analytical chemistry with focus on various immunoassays platforms as well as liquid chromatography and mass spectrometry.
* Expertise in analyzing endogenous biomarkers using immunoassay platforms (ELISA, MSD, Luminex, SIMOA, Clinical analyzers)
* Expertise in quantitatively analyzing endogenous biomarkers such as polar metabolites, lipids, peptides and proteins using liquid chromatography mass spectrometry
* Hands on research experience of ex vivo work on urinary extracellular vesicles and various blood cell populations
* Ability to plan and report all work to appropriate standards (Good Laboratory Standard, GLS)
* Good project management and matrix leadership skills, ability to collaborate well cross functions
* Passion for delivering and promoting excellence in science.
* Excellent English communication skills, both verbal and written