Senior Scientist, Bioscience In Vivo - Immunology

Are you an experienced in vivo Scientist ready to apply your skills in a diverse and dynamic company? If you can envision providing scientific expertise in a role that can impact patients' lives - join us now!


We are now looking to recruit an In Vivo Scientist with an immunology profile and a drive for innovation and idea generation as well as excellent laboratory skills to join the Bioscience In Vivo Department, within Early Respiratory & Immunology. The role is located at our vibrant R&D site located in Gothenburg, Sweden.


At AstraZeneca, we believe in the potential of our people and you will develop beyond what you thought possible. We make the most of your skills and passion by actively supporting you to see what you can achieve no matter where you start with us.


Respiratory & Immunology is one of AstraZeneca's main therapy areas. From a research perspective we work to understand, treat, modify and ultimately cure respiratory and autoimmune diseases with an emphasis on inflammatory bowel disease (IBD), systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), atopic dermatitis (AD).


The successful candidate will join a highly motivated team that works closely together with other departments focusing on Target Translational Science, Bioscience In vitro assays and Drug Metabolism/Pharmacokinetics, to support discovery projects and to drive new exciting research. Are you ready to join us?


What you'll do
As a Senior Scientist, Immunology you are a vital member of the in vivo team and will contribute to the progress of our drug discovery projects. You will actively take part in scientific discussions, represent the department in project meetings, gain input from other functions and incorporate in vitro as well as pharmacokinetic data in the experimental design.


This is a partly lab-based role where you will be actively involved in the design, planning and execution of the experiments, with the responsibility to coordinate, perform and analyze in vivo experiments. You will independently assess and report data with a clear understanding of its reliability, interpretation of findings and draw appropriate conclusions.


We are looking for a team player with a strong background in innate and adaptive immunity, experience in animal hands-on work, skills in cellular- and molecular biology techniques and knowledge in pre-clinical drug discovery.


Essential for the role
* PhD in immunology, ideally complemented by a number of years working in a drug discovery environment
* Ability to independently design and perform in vivo disease and mechanistic models, including administration of candidate drugs, collection of biological samples and ex vivo biomarker analysis
* Research experience within autoimmune and autoinflammatory diseases and basic understanding of PK/PD relationships
* Excellent hands-on in vivo skills within animal models of autoimmune diseases with a special focus on gut immunology and IBD (such as, naïve CD4+ T cell transfer, DSS, anti-CD40, TNBS…)
* Experience with cell isolation from lamina propria, flow cytometry and various cellular and molecular biology techniques for the measurement of proteins (ELISA, western blot, Meso Scale Discovery technology platform), and gene expression (qRT-PCR)
* Experience of maintaining the highest standards of welfare and ethical compliance as well as ensuring the integrity of the data generated. Familiar with using Good Statistical Practice in animal research and applying the 3R's (reduction, refinement and replacement) across the full range of studies
* Excellent English written and oral communication skills, including presentation skills. You are organized and incorporate the views of others in your communication and collaboration


Desirable for the role
* Valid education required for compliance to work with live animals in Sweden
* Good written and oral communication skills in Swedish and experience in writing ethical applications for animal work in Sweden
* Good understanding of pharmacology and physiology
* Understanding and experience with animal models of arthritis (e.g. collagen induced arthritis) and/or lupus (e.g. NZB/WF1)
* Understanding of statistical methods, quality control and data reporting/archiving
* Knowledge in immunohistochemistry, histology scoring and histomorphometry
* Experience in preclinical MRI, CT, SPECT or optical imaging





About AstraZeneca Gothenburg Hub
Our stunning campus in Gothenburg is one of AstraZeneca's three strategic science centers. The site is home to over 2,500 employees, from 50 different nationalities. Gothenburg includes the complete range of functions, and as such offers plenty of development opportunities for a wide range of professionals. Our science teams in Gothenburg collaborate with academic and industry partners in Sweden and globally. And the site itself has been designed with collaboration in mind. From the Coffee Lab to exercise areas, we've built a series of environments where innovation can happen.

So, what's next!
Are you already imagining yourself joining our team? Good, because we can't wait to hear from you. Welcome with your application no later than June 1, 2022.