Senior Scientist, Bioscience In Vivo - Inhalation & Imaging

Are you an experienced Scientist ready to apply your skills in a diverse and dynamic company? If you can envision providing scientific expertise in a role that can impact patients' lives - join us now!


We are now looking to recruit an In Vivo Scientist with experience in pre-clinical inhalation and ideally also imaging techniques with a drive for innovation and idea generation as well as excellent laboratory skills to join the Bioscience In Vivo Department within the Early Respiratory & Immunology. The role is located at our vibrant R&D site in Gothenburg, Sweden.



At AstraZeneca, we believe in the potential of our people and you will develop beyond what you thought possible. We make the most of your skills and passion by actively supporting you to see what you can achieve no matter where you start with us.



Respiratory & Immunology is one of AstraZeneca's main therapy areas. From a research perspective we work to understand, treat, modify and ultimately cure respiratory and autoimmune diseases with significant unmet medical need.



The successful candidate will join a highly motivated team that works closely together with other departments focusing on Target Translational Science, Bioscience In vitro assays and Drug Metabolism/Pharmacokinetics to support discovery projects and to drive new exciting research. Are you ready to join us?



What you will do
As a Senior Scientist, Inhalation & Imaging you are a vital member of the in vivo team and will contribute to the progress of our drug discovery projects. You will drive science and develop valuable solutions for respiratory diseases and provide scientific and technical inhaled drug delivery expertise.



This is mainly a lab-based role. You will be actively involved in the design, planning and execution of experiments with responsibility to coordinate, perform and analyze experiments as well as maintaining and developing models of aerosol delivery. You will independently assess and report data with a clear understanding of its reliability, interpretation of findings and draw appropriate conclusions.

We are looking for a team player with a strong background and hands-on experience in various rodent aerosol generation and delivery platform ideally complemented by experience in imaging techniques in rodents, a problem-solving attitude and knowledge in pre-clinical drug discovery.



Essential for the role
● PhD in a relevant discipline (area of Bioscience) ideally complemented by a number of years working in a drug discovery environment with relevant responsibilities for this role
● Experience in the operation and development of inhalation exposure systems (box inhalation, tower inhalation) including the characterization of test aerosols for reproducibility and particle size or strong interest in internal education in this field
● Experience with rodent smoke exposure systems
● Experience in preclinical MRI, CT, SPECT or optical imaging
● Excellent hands-on in vivo skills and a valid education required for compliance to work with live animals in Sweden
● Respiratory and/or immunology disease knowledge and basic understanding of PKPD relationships
● Excellent written and oral communication skills, including presentation skills. You are organized and incorporate the views of others in your communication and collaboration
● Experience of maintaining the highest standards of welfare and ethical compliance as well as ensuring the integrity of the data generated. Familiar with using Good Statistical Practice in animal research and applying the 3R's (reduction, refinement and replacement) across the full range of studies



Desirable for the role
● Good knowledge in technical engineering and software/computer tools
● Experience in various cellular and molecular biology techniques for the measurement of protein expression and activation (eg ELISA, Western Blot, FACS, Meso Scale Discovery (MSD) technology platform), and RNA (qRT-PCR, RNASeq)
● Good written and oral communication skills in Swedish and experience in writing ethical applications for animal work in Sweden



Why AstraZeneca?
AstraZeneca is a global, innovation-driven BioPharmaceutical business that focuses on the discovery, development and commercialisation of prescription medicines for some of the world's most serious disease. But we're more than one of the world's leading pharmaceutical companies.



About AstraZeneca Gothenburg Hub
Our stunning campus in Gothenburg is one of AstraZeneca's three strategic science centers. The site is home to over 2,500 employees, from 50 different nationalities. Gothenburg includes the complete range of functions, and as such offers plenty of development opportunities for a wide range of professionals. Our science teams in Gothenburg collaborate with academic and industry partners in Sweden and globally. And the site itself has been designed with collaboration in mind. From the Coffee Lab to exercise areas, we've built a series of environments where innovation can happen.

So, what's next!
Are you already imagining yourself joining our team? Good, because we can't wait to hear from you. Welcome with your application no later than June 1, 2022.