Senior Scientist Formulation/Biologics

This is a unique opportunity for an enthusiastic, innovative and motivated scientist to join the Advanced Drug Delivery teams at our Gothenburg site. Join us and become a member of a dedicated team, working with drug delivery of challenging drug molecules closely together with analysts, chemists and cell biologists in our common effort to drive the projects forward.

AstraZeneca is a major international healthcare business engaged in the research, development, manufacture and marketing of prescription pharmaceuticals and the supply of healthcare services. But we're more than one of the world's leading pharmaceutical companies. At AstraZeneca, we're proud to have a unique workplace culture that inspires innovation and collaboration. Here, employees are empowered to express diverse perspectives - and are made to feel valued, energized and rewarded for their ideas and creativity.

Within Advanced Drug Delivery (ADD), a sub-division of Pharmaceutical Sciences (PS), we focus on drug delivery and parenteral administration in the field of complex synthetic molecules and biomolecules such as peptides, oligonucleotides and polynucleotides. We have the responsibility to progress the candidate compounds from early pre-clinical phase up to Proof of Concept in humans.

We are now looking for a skilled experimentalist who will focus on intracellular delivery of biological molecules. The role covers development of advanced formulation methods to be used in both preclinical phase and early clinical phase (phase I/IIa), building an understanding of transport over the cell membrane and the intracellular fate of the drug.

Main Duties and Responsibilities
- Develop and characterize different delivery systems for biomolecules, supporting projects in preclinical and clinical phase.
- Collaborate closely with other internal functions and external partners to build our capabilities in intracellular drug delivery.
- Generate, assess and report data with a clear understanding of its reliability, interpret findings and draw authoritative conclusions and recommendations so that their significance can be appreciated. Engage customers in development of solutions by applying a broader perspective.
- Ensure that work is performed in accordance with current working principles and quality system with appropriate safety (SHE). Maintain knowledge of the regulatory and compliance guidelines as related to the role.
- Prepare documentation and formal reports in accordance with current standards and where appropriate to GMP. Generate CMC documents for regulatory submissions or enquiries.
- Apply technical knowledge to drug projects and the evaluation of new technologies /processes. Collaboration with specialist scientific and/or technology networks.
- May supervise co-workers and contribute to their training and development by acting as coach/mentor.
- Will work as a member of cross-functional project teams, with a large degree of independence representing own group and area of expertise.

Essential Requirements
- Educational background at research level (PhD) or a Masters exam with work experience in an area relevant to Biotechnology, Biochemistry, Molecular Biology or similar.
- Experience in working with oligonucleotides, peptides or other compounds of high complexity.
- Knowledge of cellular uptake mechanisms, targeting and basic immunology.
- Understanding of suitable quality standards (e.g., GLP and GMP)

Desirable Requirements
- Experience of macromolecular based systems such as polymers, lipids and different conjugates.
- Experience of different formulation systems/matrixes for biological molecules.
- Technical competence in the field of injectable drug formulation development and sustained release (e.g. parenterals, biologics) is desirable.
- Experience from working with pharmaceutical development.
- Ability to author scientific publications.
- Ability to understand quantitative and qualitative data from in-vitro assays and relate data to quality and stability of the active pharmaceutical molecule.
- Experience in bioassays, cell culturing and imaging.
- Good verbal and written communication skills.

If you are interested, apply now!

For more information regarding the role please contact Andreas Höijer, Team Leader (+46 31 7762966, +46 708 467421).

Welcome with your application no later than 18 April, 2017.

AstraZeneca is an equal opportunity employer. AstraZeneca will consider all qualified applicants for employment without discrimination on grounds of disability, sex or sexual orientation, pregnancy or maternity leave status, race or national or ethnic origin, age, religion or belief, gender identity or re-assignment, marital or civil partnership status, protected veteran status (if applicable) or any other characteristic protected by law. AstraZeneca only employs individuals with the right to work in the country/ies where the role is advertised.

More than ever, science is accelerating our rate of understanding in a wide range of medical fields – and that’s only set to increase. As a global, science-led biopharmaceutical business, AstraZeneca is at the forefront of that evolution. That means an unparalleled product portfolio and a strong pipeline across all stages of the drug development process. Everything we do comes back to improving the health of our patients worldwide, and to make that happen we’re focusing on some of the most challenging diseases facing humanity today.

We have a highly collaborative culture, where you’ll be encouraged to push the boundaries of science while developing industry-recognised skills and experiences.