Senior Scientist - High-content imaging and assay development

Are you an experienced scientist in the field of high-content imaging and advanced analysis? Would you like to combine your scientific skills & curiosity to establish robust assays with human stem cell-derived in vitro models of disease and elucidate novel disease mechanisms? This might be the next challenge for you!

At AstraZeneca in Gothenburg, Sweden we have an exciting opportunity for you to join us in the Applied Stem Cell Sciences team in Translational Genomics, Discovery Sciences, Biopharmaceuticals R&D, as a bench-based Senior Research Scientist to be a key player in developing high-content imaging based assays using advanced cell models.

The role

Working alongside our stem cell scientists, disease area specialists, genome editing group, and computational biology experts you will have the opportunity to work on scaleable cellular models in multiple indications to design and execute complex cell-based assays for target validation and mid-throughput screens for target identification.

The role is focused on laboratory-based activities. Your biggest impact will be through significant contributions to the practical delivery to projects in compliance with AstraZeneca corporate responsibility, policies and relevant safety standards.

It is essential to have good social and communication skills, be collaborative and a strong team player. Candidates should be able to work independently, take own initiatives and have a positive, goal oriented and problem-solving attitude.

Good organizational, data management and documentation skills are required, and you should be comfortable in presenting your results. English language is required, both spoken and in writing.


Key Skills and Responsibilities:

* MSc/PhD degree with significant experience in Neuroscience or Cell Biology
* Minimum 3+ years experience in using automated (e.g. Yokogawa, Molecular Devices) and conventional fluorescent and confocal imaging systems (e.g. Zeiss, Nikon)
* Demonstrable skills across a broad range of image analysis and data analytics tools (Cell Profiler, ImageJ, Spotfire)
* Design and execute complex cell-based assays and mid-throughput screens using imaging-based readouts as well as other readouts as needed
* Troubleshoot batch effects, imaging protocol selection, cell- and compound-dispensing, data acquisition and instrument scheduling
* Collaborate effectively with Quantitative Biology and Machine Learning teams to optimize image analysis strategies, statistical analysis and model building

The following skills are highly desirable:

* Familiarity with human 2D and 3D cellular assays using primary or hiPSC-derived cells types.
* Experience with setting up cell-based pharmacological assays
* Familiarity with arrayed genetic screens including CRISPR-based approaches
* Experience with automated liquid handling systems (i.e., Bravo, Tecan, Hamilton or similar) and lab automation in context of cell-based screening

Why AstraZeneca?

Thrive in a place where the brightest and most curious minds seamlessly come together in our inclusive environment. With more than 2,800 employees from over than 60 countries, our vibrant Gothenburg site is a truly inspiring place to work. Here, the history and future of scientific breakthrough come together. We believe that the diversity of our people is crucial to bringing new discoveries to life.

So what's next? If this sounds like the next job and place for you, apply today!

We look forward to get to know you better - please send your application to us as soon as possible, but no later than 28th August, 2022.

For more information about the position please contact Bilada Bilican at bilada.bilican(at)astrazeneca.com.

Additional information:
Our Gothenburg site: https://www.astrazeneca.com/our-science/gothenburg.html
Life in Gothenburg: https://www.movetogothenburg.com/
Make a move to Global Gothenburg: https://www.youtube.com/watch?v=c-Iqbb4aw38
About BioPharmaceuticals R&D: https://www.astrazeneca.com/r-d.html