Senior Scientist - Immune Cell Therapy

Are you an experienced scientist in the field of immune cell therapy? Would you like to apply your immunology expertise and turn your ideas into life-changing cell-based medicines for the non-oncology diseases? Join us and be a key player in the build of our new Biopharmaceuticals R&D Cell Therapy department. Together we will push the boundaries of Science!

At AstraZeneca, you will be empowered to be innovative and creative where difference is valued. We thrive in a place where the brightest and most curious minds seamlessly come together in our inclusive environment. The role will be placed at AstraZeneca's dynamic R&D site in the lovely city of Gothenburg, Sweden. Here you will be part of an international, open-minded and creative working atmosphere based on collaboration and innovation.

Biopharmaceuticals R&D is committed to the development of next-generation innovative medicines, and we are building a Cell Therapy Department to establish AstraZeneca as a world leader in Cell Therapy across disease areas within Cardiovascular, Renal and Metabolism (CVRM) and Respiratory and Inflammation (R&I). The Cell Therapy Department will bring together >50 specialists across Europe and the U.S. to support the organization with cell therapy expertise and capabilities, while working in close collaboration with experts across AstraZeneca globally to leverage the existing and emerging cell platforms, novel cell engineering and gene editing technologies.

What you'll do

Building on your background in immunology you will apply your skills in a regenerative medicine setting, working collaboratively with project leaders, in vitro, and in vivo scientists, and therapy area specialists to ensure efficient progress of Cell Therapy projects. The role is focused on laboratory-based activities and you will use your scientific expertise to design and run experiments and deliver high quality data.

You will play a leading role in developing our scientific capabilities and presenting your work both internally and externally, working in a highly cross disciplinary environment with local and international colleagues.

Accountabilities include:

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Independently assess and report data with little or no guidance, in a clear and concise manner, with an understanding of its implications within the overall context of drug discovery to support project decisions and milestones
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Communicate and share relevant information between distinct projects within the bioscience department as well as across other functions and externally
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Keep up to date with relevant scientific literature and technology platforms as well as writing and publishing scientific papers
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May lead projects and a small team of project researchers.

Essential for the role

In this role it is essential to have good social and communication skills, be collaborative and a strong team player. You should be able to work independently, take own initiatives and have a positive, goal oriented and problem-solving attitude. You also have:

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Ph.D. in Cell Biology, Immunology, or a related discipline, with relevant academic or industrial experience
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Strong background in cell and molecular immunology with experience in CAR-T, Natural Killer, T regulatory cells, macrophages, or other immune cell therapy development
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Extensive experience in culturing and expanding immune cells
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Proficiency in assays interrogating immune cell function, such as cellular activation, cytokine release, proliferation, cytotoxicity/suppression, multi-parameter flow cytometry
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Excellent presentation, communication, and organizational skills

Desirable for the role

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Track record of high-quality publications, patents, and/or developing pipeline projects in a pharmaceutical or biotechnology setting
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Experience with gene engineering/editing of primary immune cells including CRISPR/Cas9, viral/ non-viral engineering, base editing, etc.
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Knowledge of mechanisms that regulate T cell- and NK cell-mediated alloreactivity and familiarity with corresponding functional assays
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Knowledge of cytokine biology
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Knowledge of monocyte/macrophage biology

So, what's next?

Are you already imagining yourself joining our team? Excellent! We look forward to your application.

Welcome with your application no later than January 22nd 2023.

Where can I find out more?

Cell Therapy Biopharmaceuticals R&D: https://www.astrazeneca.com/r-d/next-generation-therapeutics/cell-therapies.html

Global Gothenburg: https://www.astrazeneca.se/om-oss/verksamheten-i-sverige/goteborg/relocate-to-gothenburg.html

Our Gothenburg site: https://www.astrazeneca.com/our-science/gothenburg.html

Why AstraZeneca?

Our Gothenburg site is one of AstraZeneca's three strategic R&D centers. With more than 2,400 employees from over than 50 countries, our vibrant Gothenburg site is a truly inspiring place to work. Here, the history and future of scientific breakthrough come together. We believe that the diversity of our people is crucial to bringing new discoveries to life.