Senior Scientist In Vitro Cardiovascular Biology

Do you have expertise within in vitro cardiovascular biology and enjoy working in the lab? Would you like to apply your expertise in a global company that is accelerating innovative science and turn ideas into life changing medicines? Join us to discover future treatment of Cardiovascular, Renal and Metabolic (CVRM) diseases!

CVRM is one of three main therapeutic research areas within AstraZeneca. Early CVRM has a patient-centric approach for discovering novel treatments for patients with cardiovascular-, chronic kidney- and metabolic disease and delivers candidate drugs into late-stage clinical development. In the Bioscience Cardiovascular department, we focus on identifying and validating new drug targets for treatment of patients with cardiovascular disease and heart failure, as well as evaluating pharmacological aspects, e.g. efficacy and mechanism of action, of potential new drug candidates. The in vitro team delivers key data to projects across all phases of the drug discovery and development process, and we work with different modalities such as small molecules, modified mRNA, antibodies, cell therapy, antisense oligonucleotides and peptides.

At AstraZeneca, we work at the cutting edge of science to develop the ground-breaking medicines of the future - here we do things that have never been done before. We put patients first and strive to meet their unmet needs worldwide.

We continually push the boundaries of science to deliver medicines that treat diseases across our main therapy areas. Through our integration with Alexion, this now includes expanding the limits of scientific research to better understand rare diseases and to discover new life-changing treatments for them.

The role is placed at AstraZeneca's dynamic R&D site in Gothenburg, Sweden, where you will work in an international environment at the fore-front of cardiovascular biology

What you'll do

As a Senior Scientist you will play a key role in driving science and projects forward. This is a lab based role where you will explore novel drug targets and support existing projects with key in vitro data. Collaboration is critical for successful delivery of drug projects and you will collaborate closely with scientists/teams from a wide range of different functions within AstraZeneca as well as with external partners and collaborators. This role will include working with in vitro biology using cell lines, pluripotent stem cells (PSC) and primary cardiovascular cells along with molecular and functional biology techniques. There will be opportunities to try novel techniques and ideas required for progressing existing portfolio and novel science and you may also take responsibility as biology lead in projects. Responsibilities include:

* Independently design, develop and run in vitro studies and assays for projects from pre-target identification to clinical stage
* Establish new methods needed in the department
* Work with molecular biology methods, imaging and assays for functional readouts such as contractility and cardiac metabolism
* Communicate data to the project teams, department, science board and at external meetings
* Contribute to communications of scientific findings through publications in scientific journals and at meetings

Essential for the role

* PhD or master's degree in biology, pharmacology or similar with strong experience in cell and molecular biology, biochemistry and relevant in vitro/ex vivo assays within the cardiovascular area
* Experience with cardiomyocyte biology and function in healthy and diseased systems by handling and manipulating relevant PSC cells and primary human and animal cardiac cell types, including cardiomyocytes
* Strong oral and written communication skills
* Excellent English, both spoken and in writing

Desirable for the role

* Experience with functional contractility systems
* Understanding the relationship between dose and level of exon skipping, as well as the relationship between level of exon skipping and efficacy
* Background in drug discovery and development in the pharmaceutical industry

So, what's next?

Are you already imagining yourself joining our team? Good, because we can't wait to hear from you!

For more information about the position please contact Erik Ryberg at erik.ryberg@astrazeneca.com

Welcome with your application no later than February 28, 2022

Where can I find out more?

Our Gothenburg site: https://www.astrazeneca.com/our-science/gothenburg.html

Global Gothenburg: https://www.astrazeneca.se/om-oss/verksamheten-i-sverige/goteborg/relocate-to-gothenburg.html

Life in Gothenburg: https://www.movetogothenburg.com/

Why AstraZeneca?

Our Gothenburg site is one of AstraZeneca's three strategic R&D centers. With more than 2,400 employees from over than 50 countries, our vibrant Gothenburg site is a truly inspiring place to work. Here, the history and future of scientific breakthrough come together. We believe that the diversity of our people is crucial to bringing new discoveries to life.

You will be offered a competitive salary and excellent benefits, such as extra paid Holiday, Private Medical Benefits, On-site exercise and much, much more.