Senior Scientist, In Vitro Imaging Specialist CVRM

Join us to be part of the discovery of future life changing medicines! At AstraZeneca we win through science, it's at the heart of our every success. That science is only possible when we work together - we'll always make sure you're clear about how your role is connected to our wider mission to show what science can do.

Right now, we are seeking a highly motivated Senior Scientist/Associate Principal Scientist to join the Cell and Molecular Pharmacology (CMP) team within the Early Cardiovascular, Renal and Metabolic (CVRM) disease area in Gothenburg, Sweden. You will apply proven imaging, image analysis and cell biology expertise providing dedicated experimental support to our drug discovery programs. In doing so you demonstrate a passion for driving scientific questions, combined with strong team working ethics. You are collaborative and a strong team player with good social and communication skills,.

In this position, you will join a team whose remit is to support drug projects in Early CVRM with efficacy and detailed mechanism of action data. We offer a highly rewarding scientific environment with ample learning opportunities and an expectation to publish new findings.

The role

This is a truly exciting senior lab-based role where you will operate in close collaboration with scientists across the Early CVRM department. The successful candidate will be responsible to manage and develop the CVRM microscopy platform, deliver high-quality microscopy data and data analysis, and support bioscientists with imaging expertise. The work includes independent planning and execution of experiments, troubleshooting and timely reporting of data according to agreed timelines. The role provides the opportunity to support CVRM projects in the therapy area co-Lead role, or Bioscience Lead role. We will also rely on you to take an active role in the local, cross-functional microscopy super-user community, in the global imaging community as well as to lead initiatives, collaborations and scientific development related to in vitro imaging.

Essential Requirements:

* PhD complemented by at least 2 years' relevant postdoctoral/professional experience or a first degree and at least 6+ years' experience within a relevant scientific discipline.
* Extensive expertise in fluorescence imaging techniques including immunofluorescence, fluorescent proteins, confocal and non-confocal high-content imaging, live-cell imaging, 3D imaging.
* Extensive expertise in advanced quantitative image analysis, with software such as Columbus, ImageJ, CellProfiler. Experience with scripting applications and machine learning is a plus.
* Scientific visibility and leadership through project contributions and external publications.
* Experience in molecular and cellular biology techniques including protein and DNA analysis, Western Blot, qPCR and cell culture.
* Excellent communication skills and an ability to operate in a multi-disciplinary research environment.
* Proven ability in providing technical leadership and guidance to others.
* Independent analysis and evaluation of complex data and delivery of data to agreed timelines.

Desirable Experiences and Abilities:

* Experience in Cardiovascular, Renal and/or Metabolic Diseases.
* Experience from either flow cytometry and FACS, histology, in vivo imaging, or medical imaging.
* Expertise in the design, development and validation of assays for high throughput drug screening.
* Proven ability to manage and develop a microscopy platform.
* Track record of identifying and adopting scientific and technical advances.
* Excellent problem-solving skills, not limited to own area of expertise.



Does this sound like your next challenge? Please apply today!

We look forward to your application no later than the 30th of August 2020.

For more information about the position please contact Erik Müllers at erik.muellers@astrazeneca.com