Senior Scientist In Vivo Cardiovascular Biology

Do you have expertise within in vivo biology and enjoy working in the lab? Would you like to apply your expertise in a global company that is accelerating innovative science and turn ideas into life changing medicines? Join us to discover future treatment of Cardiovascular, Renal and Metabolic (CVRM) diseases!

CVRM is one of three main therapeutic research areas within AstraZeneca. Early CVRM has a patient-centric approach for discovering novel treatments for patients with cardiovascular-, chronic kidney- and metabolic disease and delivers candidate drugs into late-stage clinical development. In the Bioscience Cardiovascular department, we focus on identifying and validating new drug targets for treatment of patients with cardiovascular disease and heart failure, as well as evaluating pharmacological aspects, e.g. efficacy and mechanism of action, of potential new drug candidates. The in vivo team delivers key data to projects across all phases of the drug discovery and development process, and we work with different modalities such as small molecules, modified mRNA, antisense oligonucleotides, stem cells and peptides.

At AstraZeneca, we work at the cutting edge of science to develop the ground-breaking medicines of the future - here we do things that have never been done before. We put patients first and strive to meet their unmet needs worldwide.

We continually push the boundaries of science to deliver medicines that treat diseases across our main therapy areas. Through our integration with Alexion, this now includes expanding the limits of scientific research to better understand rare diseases and to discover new life-changing treatments for them.

The role is placed at AstraZeneca's dynamic R&D site in Gothenburg, Sweden, where you will work in an international environment at the fore-front of cardiovascular biology.



What you'll do

As a Senior Scientist, In Vivo Cardiovascular Biology, you will play a key role in driving science and projects within the cardiovascular area forward. This is a lab based role where you will explore novel drug targets and support existing projects with key in vivo and ex vivo data. Collaboration is critical for successful delivery of drug projects and you will work closely with scientists/teams from a wide range of different functions within AstraZeneca as well as with external partners and collaborators. Your in vivo work will include experimental work in small and/or large animals to broaden the pharmacodynamic and pharmacokinetic understanding of our new drug candidates as well as cardiovascular disease. You will perform surgical procedures when needed and measure physiological parameters invasively and non-invasively (e.g. with cardiac catheterization and by ultrasound imaging). You will have the opportunity to explore novel techniques and ideas required for progressing existing portfolio and novel science. Some in vitro work can also be part of the role description. You may also establish new animal disease models that recapitulate disease phenotypes and take responsibility as biology/pharmacology lead in projects. Responsibilities include:

* Independently design, develop, and run experiments as well as analyse results, interpret data and report in vivo studies and ex vivo assays for projects from pre-target identification to clinical stage
* Communicate data and scientific findings at internal and external meetings and through publications in scientific journals
* Proactively contribute to a vibrant and innovative working environment where improvements and new ideas are adopted and freely shared



Essential for the role

* Master's or PhD in biology, pharmacology or similar and a scientific background in any of the following fields: cardiovascular disease, heart failure, cardiac regenerative medicine, cardiac metabolism, genetic cardiomyopathies
* Hands-on experience and expertise in handling small and/or large animals and performing in vivo experiments accordingly
* Knowledge in physiology, anatomy and experience in how to measure functional & morphological changes in vivo within the cardiovascular area
* Entrepreneurial, collaborative and flexible ways of working
* Strong oral and written communication skills
* Excellent English, both spoken and in writing



Desirable for the role

* Experience with performing open chest surgeries, such as myocardial infarction and intramyocardial injections
* Knowledge and experience in ultrasound imaging and/or MRI imaging
* Background in drug discovery and development in the pharmaceutical industry



So, what's next?

Are you already imagining yourself joining our team? Good, because we can't wait to hear from you!

For more information about the position please contact Karin Åvall at Karin.Avall@astrazeneca.com

Welcome with your application no later than, April 30, 2022.



Where can I find out more?

Our Gothenburg site: https://www.astrazeneca.com/our-science/gothenburg.html

Life in Gothenburg: https://www.movetogothenburg.com/

Culture and atmosphere of the Gothenburg site: https://www.linkedin.com/feed/update/urn:li:activity:6496327311678410752/