Senior Scientist - Innovative in vivo gene engineer

Are you a passionate In vivo biologist that is excited by the idea of contributing to the creation of a novel treatment for rare diseases? Are you ready to innovate and develop therapeutics to alter or edit the genome? If yes, then this exciting role at AstraZeneca is for you!


Take the opportunity to join the Genome Engineering In Vivo team at our vibrant AstraZeneca R&D site in Gothenburg, Sweden, as we are looking for a Senior Scientist with focus on in vivo genome modification.

In this exciting role, you will play an important part in our growing Genome Engineering department. We are working within the broader Discovery Science organisation with a common goal to develop novel treatments utilizing science and technology. We identify new targets, create reagents, assays and disease models to discover new medicines, and to develop gene therapies. We want to harness the full potential of oligonucleotide-based therapies by optimising delivery, stability, and specificity.



Here you can thrive in a place where the brightest and most curious minds seamlessly come together in our inclusive environment.


What you'll do:
You will use your innovative thinking to explore the in vivo delivery of new genome editing technologies. In this lab-based in vivo senior scientist role, you will be part of a team responsible for developing and testing tissue specific delivery of oligonucleotide and CRISPR-Cas9 related technologies to mice and rats. Leveraging your understanding and experience in genome editing you will have the opportunity to apply your knowledge to gene therapy projects. You will assess the efficiency of genome editing in vivo by next generation sequencing or biomarker assays. You will be involved in all stages of a project; plan, design, execute and analyse data from experiments to generate high quality results to support project decisions and milestones.



Essential for the role:
The right candidate for this position is a motivated team member who enjoys collaboration and interacting across our AZ global functions and fields. It is important for you to do the right thing - and this goes hand in hand with your good organisational, data management and documentation skills, effective problem-solving and a strong delivery focus. You should also have;

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Have academic or industrial experience or a Ph.D. in a relevant discipline.
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A passion for and experience with working 'hands on' with in vivo studies; skilled in delivery and sampling in rodents for biochemical assay and distribution analysis.
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Experience with in vivo study planning documentation and animal welfare monitoring routines
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Fluent in Swedish to be able to write and submit ethical applications
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Knowledge of genome editing tools and expertise with analysis of genome editing outcomes, NGS.
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Collaborative mentality, great communication skills and a passion for caring when working in vivo.



Why AstraZeneca?
Join the team unlocking the power of what science can do. We are working towards treating, preventing, modifying and even curing some of the world's most complex diseases. Here we have the potential to grow our pipeline and positively impact the lives of billions of patients around the world.



So, what's next? If this sounds like the place and job for you - welcome to apply today!

We look forward to getting to know you better. Send in your application as soon as possible, but no later than August 26, 2024.