Senior Scientist - Innovative in vivo Mouse Models

Are you a passionate In vivo biologist that enjoys generating new disease relevant mouse models utilizing tools such as CRISPR-Cas9? Do you also have experience or an interest in delivery of CRISPR-Cas9 reagents? If yes, it's a match with this exciting role at AstraZeneca!

Take the opportunity to join the Genome Engineering In Vivo Models team at our vibrant AstraZeneca R&D site in Gothenburg, Sweden, as we are looking for two Senior Scientists with focus on in vivo genome modification.

In this exciting role, you will play an important part in our growing Genome Engineering department. We are working within the broader Discovery Biology organisation with a common goal to innovate at the interface of science and technology. We discover new targets, create reagents, assays and disease models to discover new medicines, and to develop cell and gene therapies.

Thrive in a place where the brightest and most curious minds seamlessly come together in our inclusive environment.

What you'll do:
In this lab-based in vivo senior scientist role, you will be part of a team responsible for the delivery of new genetically engineered mouse models for oncology generated by CRISPR-Cas9 and related technologies. Leveraging your strong knowledge and experience in genome editing you will also have the opportunity to apply your knowledge to gene therapy projects. You will get the opportunity to use your innovative thinking to explore the in vivo delivery of new editing technologies.

In your everyday work our in vivo scientists design and develop genome editing-based strategies to generate and confirm by sequencing new mouse models of human cancer. Our scientists also test delivery tools such as LNP and viral vectors, to improve the efficiency of genome editing in vivo. You will be involved in all stages of projects; plan, design, execute and analyse data from experiments to generate high quality results to support project decisions and milestones. As well, you will present the outcome to the project teams and prepare written reports

Essential for the role:
The right candidate for this position is an innovative team member who enjoys collaboration and interacting across our AZ global functions and fields. It is important for you to do the right thing - and this goes hand in hand with your good organisational, data management and documentation skills, with effective problem-solving and a strong delivery focus. You should also have;

* Knowledge and experience with genome editing tools (Cas9, base or prime editors).
* Expertise in and a passion for working 'hands on' in vivo work and delivery of CRISPR reagents.
* Expertise with analysis of genome editing outcomes, on and off target analysis, NGS.
* Have academic or industrial experience or a Ph.D. in a relevant discipline.
* Collaborative mentality, great communication skills and a passion for in vivo.

Why AstraZeneca?
Join the team unlocking the power of what science can do. We are working towards treating, preventing, modifying and even curing some of the world's most complex diseases. Here we have the potential to grow our pipeline and positively impact the lives of billions of patients around the world.

So, what's next? If this sounds like the place and job for you - welcome to apply today!

We look forward to get to know you better. Send in your application as soon as possible, but no later than 16th January, 2021.

For more information about the position please contact hiring manager Michelle Porritt at michelle.porritt@astrazeneca.com

Additional information:
Our Gothenburg site: https://www.astrazeneca.com/our-science/gothenburg.html
Life in Gothenburg: https://www.movetogothenburg.com/
Make a move to Global Gothenburg: https://www.youtube.com/watch?v=c-Iqbb4aw38
About BioPharmaceuticals R&D: https://www.astrazeneca.com/r-d.html

NOTE - Due to the Christmas holidays approaching quickly, the screening process may take a bit longer than usual - please bear with us and we will get back to you as soon as possible when we are back at work in January!