Senior Scientist - Integrated Bioanalysis

Are you a passionate and experienced scientist that enjoys hands-on lab work? Do you also want to work in a great team that have the common goal to push the boundaries of science? If yes, this might be the opening for you!

We are looking for a highly motivated Senior Scientist to join our Integrated Bioanalysis organisation. The position is based at our R&D site in Gothenburg, Sweden and you will take a leading part in the lab designing bioanalysis method strategies and interpreting data generated in support of new modality projects that will advance our drug pipeline.

This role is placed in our Discovery Bioanalysis Europe team which is part of the Clinical Pharmacology and Safety Sciences (CPSS) function. Where we are responsible for the analysis of nucleotide, protein, monoclonal antibody and gene and cell therapeutics and non-clinical safety biomarkers in biological and invitro samples generated in support of non GLP pharmacokinetic, pharmacodynamic and investigational safety studies.

We continually push the boundaries of science to deliver medicines that treat diseases across our main therapy areas. Through our integration with Alexion, this now includes expanding the limits of scientific research to better understand rare diseases and to discover new life-changing treatments for them.

What you'll do:
Your principle responsibility will be in the lab - designing, developing, and interpreting assays and data to support discovery drug program transition through to lead candidate selection. Using a range of innovative analytical methodologies, this position will work to develop novel methods for the pharmacokinetic measurement of therapeutic gene editing, protein and nucleotide therapeutics.

You will be expected to represent the department on multidiscipline drug discovery teams spanning a number of different therapeutic modalities, thus ability to utilise a range of technologies in the lab will be essential such as PCR, ligand binding, branched-DNA and hybridisation ELISA. You will report into a Head of Discovery Bioanalysis EU and be expected to take a lead role in pushing the boundaries of what is possible for new modality therapeutics bioanalyses.

Essential in the role:

* A strong background in a biological or chemical related discipline with extensive experience of developing methods for the quantitative measurement of biotherapeutics such as therapeutic gene editing, nucleotides and proteins.
* A high level of independence and with an ability to develop hypotheses and execute analysis plans for pharmacokinetics, pharmacodynamics and biomarker data.
* Attention to detail, good communication, and collaboration skills. Outstanding record keeping skills are critical for success.
* An ability to think and act creatively- independently, and within collaborations.

Desirable in the role:

* Experience with advanced data analysis tools for analyzing and visualizing pharmacokinetic and biomarker data.
* Operational experience with HPLC-MS/MS for measurement of proteins and nucleotides.
* A proven track record of publication in gene editing, nucleotide and / or large molecule. bioanalysis field. Innovative and influential leader, capable of developing strategic approaches to analytical challenges.

Why AstraZeneca?
Be part of a dedicated Research & Development team. Fuelled by our commitment to help more patients, strengthen our pipeline and grow our area. Thrive in a place where the brightest and most curious minds seamlessly come together in our inclusive environment.

So, what's next? If this sounds like your next challenge - welcome to apply today!

We look forward to your application, but no later than 27th February, 2022.

Additional information:
Our Gothenburg site: https://www.astrazeneca.com/our-science/gothenburg.html
Life in Gothenburg: https://www.movetogothenburg.com/
Make a move to Global Gothenburg: https://www.youtube.com/watch?v=c-Iqbb4aw38
About BioPharmaceuticals R&D: https://www.astrazeneca.com/r-d.html