Senior Scientist, Large Scale Synthetic Chemistry

Are you an experienced organic chemist with expertise in large scale synthetic chemistry? Are you excited by challenging, creative chemistry and state of the art equipment for large scale synthesis? Then you might be the one we are looking for! Join AstraZeneca and apply your expertise in a company that follows the science and turns ideas into life changing medicines.

We are now looking to recruit a Senior Scientist focused on large scale synthetic chemistry to join the Early Chemical Development (ECD) function within Pharmaceutical Sciences at AstraZeneca. The position is placed at AstraZeneca's vibrant R&D site in Gothenburg, Sweden.

Pharmaceutical Sciences at AstraZeneca deliver the therapies of the future through scientific leadership in drug delivery, design of synthetic routes, and manufacturing of Active Pharmaceutical Ingredients (API) across all the AstraZeneca therapy areas.

The ECD team is responsible for developing manufacturing routes and processes as well as delivering batches of drug substance for all projects in the late discovery and early development portfolio.

The Large Scale Synthetic Chemistry team in Gothenburg delivers high-quality API batches in the range of 100-1000 g through development of great chemistry, innovative routes and creative solutions. The laboratory is the single company wide asset for large scale, non-GMP manufacturing of API for pre-clinical toxicology studies for all therapy areas.

We support the projects with the highest priority, most technically challenging chemistry in the AstraZeneca early phase portfolio and have access to top-quality labs and equipment, including e.g. reactors up to 100L, flow- and high-pressure reactors, and a wide range of modern analytical instruments.

Main Duties and Responsibilities

As a member of the Large Scale Synthetic Chemistry team, you will work closely with both medicinal chemists in drug development projects and process chemists to explore and develop safe, efficient and cost-effective synthesis routes to produce drug candidates. Key deliverables are:

* With strong emphasis on SHE aspects, explore and develop experimental strategies, troubleshoot problems and synthesize organic molecules in the range of 100-1000 grams
* Plan, prioritise and perform own work and actively collaborate with the drug project synthesis teams.
* Demonstrate expertise in synthetic and analytical chemistry, purification and crystallisation
* Provide stringent documentation of experimental results in an electronic labjournal, as well as writing up campaign and development reports.
* Publish novel work in peer reviewed journals

Essential for the role

* Ph.D. degree or equivalent in Organic Chemistry
* Post-graduate research experience, preferably from work with route development and large-scale synthesis of complex organic molecules
* Strong theoretical and practical knowledge of organic chemistry, with good awareness of current developments in the literature
* Able to identify, develop and apply new technologies and ways of working within large scale synthetic organic chemistry
* Ability to independently design, plan and execute multistep syntheses to be able to manufacture kilogram campaigns together with team members
* Creativity in handling a wide range of synthetic challenges
* Ability to coach peers for enhanced individual and team performance and development
* Strong collaborative and communication skills with experience of interacting effectively and work collaboratively across interfaces of disciplines
* Curious and innovative mindset
* Passion for solving complex synthetic problems and demonstrate proof of concept for new route



Are you ready to bring new ideas and fresh thinking to the table? Then you might be the one we are looking for!

We encourage you to send your application as soon as possible, since interviews will be held continuously, but no later than February 1st, 2021.

For more information please contact recruiting manager Hans Emtenäs at hans.emtenas@astrazeneca.com

Learn more about AstraZeneca Gothenburg: https://www.astrazeneca.com/our-science/gothenburg.html