Senior Scientist, Large Scale Synthetic Chemistry

Are you an experienced organic chemist with expertise in large scale synthetic chemistry? Are you excited by challenging, creative chemistry and state of the art equipment for large scale synthesis? Then you might be the person we are looking for! Join AstraZeneca and apply your expertise in a company that follows the science and turns ideas into life changing medicines.



The role

We are seeking a new member to join our Large Scale Synthetic Chemistry team as a Senior Scientist. Working within our Early Chemical Development function you will be located at AstraZeneca's vibrant R&D site in Gothenburg, Sweden.

Early Chemical Development (ECD) is a World-Class CMC department within Pharmaceutical Sciences whose responsibilities span from early engagement with Discovery Chemistry groups to manufacture of Phase II Clinical trial materials. Its key skill areas include Analytical Chemistry, Crystallisation, Isotope Chemistry, Large-Scale Laboratory (Kilo-Lab) Manufacturing, Process Chemistry, Process Engineering and Separation Science.

The Large Scale Synthetic Chemistry team sits within ECD and delivers high-quality API material in the range of 100-1000 g through development of excellent chemistry, innovative routes and creative solutions. The laboratory is the single company wide asset for large scale, non-GMP manufacturing of API for pre-clinical toxicology studies.



What you'll do

As a member of the Large Scale Synthetic Chemistry team, you will work closely with both medicinal chemists and process chemists to explore and develop safe, efficient and cost-effective synthesis routes to drug candidates.



Your main accountabilities/responsibilities:

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With strong emphasis on safety you will explore and develop experimental strategies, troubleshoot problems and synthesize organic compounds in the range of 100-1000 grams.
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Plan, prioritise and perform your own work and actively collaborate with the drug project synthesis teams.
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Demonstrate expertise in synthetic and analytical chemistry, purification and crystallisation.
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Provide rigorous documentation of experimental results in an electronic laboratory journal, and author development/campaign reports.
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Publish novel work in peer reviewed journals.



Essential qualifications:

A Ph.D. or equivalent in organic chemistry, or extensive directly relevant experience is required. It is likely that you will have post-graduate research experience, preferably within route development and large-scale synthesis of complex organic molecules.

You will have excellent collaboration, communication, and planning skills with a strong sense of responsibility, teamwork and delivery focus.



Other qualifications:

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Strong theoretical and practical knowledge of organic chemistry, with good awareness of current developments in the literature
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Ability to independently design, plan and execute multistep syntheses suitable for kilogram manufacture.
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Able to identify, develop and apply new technologies and ways of working within large scale synthetic organic chemistry
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Creativity in handling a wide range of synthetic challenges and a passion for complex problem solving.
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Ability to coach peers to enhance individual and team performance and development
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Curious and innovative mindset



So, what's next?

Are you ready to bring new ideas and fresh thinking to the table? Then you might be the one we are looking for! We would welcome with your application (CV and cover letter) no later than Nov 4, 2022.

For more information please contact the recruiting manager Hans Emtenäs, hans.emtenas@astrazeneca.com



Where can I find out more?

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