Senior Scientist - Molecular Biology, Genome Engineering

Here at AstraZeneca, we are working towards turning novel state-of-art technologies into effective and safe medicines for severe genetic disease. Do you want to be part of this effort? Welcome to join our exciting journey!

As our new Senior Research Scientist, you will be a part of the Therapeutic Editing team in the Department of Genome Engineering. The role is based in Gothenburg, Sweden, where you will join an international team that develops novel genome engineering technologies and applies these technologies for generation of therapeutic agents. We provide a stimulating environment for innovation and translational application of genome engineering tools, to turn them into effective and safe medicines.

We continually push the boundaries of science to deliver medicines that treat diseases across our main therapy areas. We expand the limits of scientific research to better understand diseases and to discover new life-changing treatments for them.

What you will do:
You will bring your scientific expertise in molecular biology and innovative thinking to develop novel genome editing tools that can potentially lead to therapies. You will be a key member in cross-functional therapeutic editing project teams with various backgrounds and expertise, where you will be responsible from gene editing strategies.

Accountabilities will include innovative optimization of genome engineering technologies to facilitate effective gene editing in target tissue types, developing relevant assays, analyzing gene editing outcomes, documenting, interpreting, and communicating results to appropriate partners. You will collaborate with other functions to develop and test novel CRISPR delivery strategies - and uphold collaborations to develop next generation sequencing approaches to analyze gene editing outcomes. Mentoring and supervising junior colleagues and postdocs is also an opportunity in this exciting role.

Essential for the role:

* PhD degree in molecular/cell biology, genetics, or relevant areas.
* Strong molecular biology background and relevant hands-on skills.
* Expertise in expression construct design and regulation of gene expression.

We also believe that our new colleague is a person who thinks outside the box and find innovative approaches to scientific problems. You hold enthusiasm and curiosity towards scientific questions and learning new skills. You can work in an independent and goal-oriented way, but you also enjoy team work and have the ability to communicate - collaborate in a global setting with cross-functional groups.

Desirable for the role:

* Experience with RNA biology or protein expression.
* Experience in viral or non-viral gene therapy delivery tools.
* Solid understanding of genome engineering.
* Experience in flow cytometry/FACS.
* Expertise in cell biology and cellular assays, such as genetic manipulation of cell lines, primary and iPS cells and evaluating genetic & functional outcomes.
* Hands on experience with RNA and protein quantification methodologies, such as RNA-seq, qPCR, western blot, MSD immunoassay etc.

Why AstraZeneca?
If you are passionate about translating scientific advances into real next generation medicines, AstraZeneca is the right place for you. Join the team for unlocking the power of what science can do. You have the potential to grow yourself, our pipeline, and positively impact the lives of billions of patients around the world.

What's next? If this sounds like a good opportunity to you - welcome to apply! Send your application as soon as possible, but no later than 23rd October, 2022.

For more information about the position, please contact hiring manager Pinar Akcakaya at pinar.akcakaya(at)astrazeneca.com.

Additional information:
Our Gothenburg site: https://www.astrazeneca.com/our-science/gothenburg.html
Life in Gothenburg: https://www.movetogothenburg.com/
Make a move to Global Gothenburg: https://www.youtube.com/watch?v=c-Iqbb4aw38