Senior Scientist - New Modalities Conjugation Chemistry

AstraZeneca R&D, New Modalities Chemistry, Gothenburg, Sweden seek to recruit an Senior Research Scientist responsible for New Modalities Conjugates in the Therapeutic Area Respiratory and Immunology (R&I).



Mission

AstraZeneca is one of the world's most exciting biopharmaceutical companies. From scientists to sales, lab techs to legal, we're on a mission to turn science into life-changing medicines that improve patients' lives and benefit society. AstraZeneca is committed to the development of the next generation innovative respiratory medicines. The department of Medicinal Chemistry in the therapeutic area of Respiratory & Immunology is focused on the delivery of Small Molecule (SM) and New Modalities (NM) clinical candidates. In this context, we are focused on growing the use of novel peptide and oligonucleotide-based modalities and molecular conjugates in the treatment of respiratory and immunological diseases.



Job description

You will be part of a team of scientists dedicated to discovering drugs based on oligonucleotide and peptide chemistry. You are expected to have a strong background in the design, synthesis, (bio)conjugation, purification and characterization of novel chemical entities by oligonucleotide focused conjugation chemistry.



Major Duties and Responsibilities

* Design and execute various (bio)conjugation strategies and techniques to prepare novel oligonucleotide conjugates.
* Contribution to identification of novel delivery technology applicable to ASO and/or siRNA therapeutics.
* Effective collaboration with project team members and colleagues in other departments
* Drive internal and external scientific visibility through publications and scientific presentations

Requirements and Qualifications

* PhD in Bio-/Organic Chemistry
* Professional experience around oligonucleotide conjugation with peptides and/or small molecules
* Knowledge of recent developments in oligonucleotide (bio-)conjugation chemistry
* Knowledge of tissue specific delivery of oligonucleotides or peptides is a bonus.
* Experience in pharmaceutical drug discovery of oligonucleotide drug candidates is a plus
* Strong scientific curiosity in novel technology and methods
* Excellent communication and collaboration skills



More information

For more information about the position please contact Wu Su, Team Leader, New Modalities Chemistry, by email: Wu.Su@astrazeneca.com or via LinkedIn. We welcome your application until January 10th, 2021.



AstraZeneca is a global, innovation-driven biopharmaceutical company that focuses on the discovery, development and commercialization of prescription medicines for some of the world's most serious diseases. In addition to being one of the world's leading pharmaceutical companies, AstraZeneca is proud to provide a unique workplace culture that inspires innovation and cross-boundary collaboration. The Respiratory, Inflammation & Autoimmunity (RIA) unit is one of AstraZeneca´s core therapy areas focused on the discovery and development of novel treatments for respiratory diseases.