Senior Scientist - NGS for High-Throughput Transcriptomics

Are you an experienced Molecular Biologist with expertise in Next Generation Sequencing (NGS)? Do you wish to apply this knowledge in a role that is connected to our wider mission to show what science can do? If yes, this might be the next role for you!

We seek a talented and engaged Molecular Biology/NGS scientist to join the Disease Molecular Profiling - NGS & Transcriptomics team at AstraZeneca in Gothenburg, Sweden. You will contribute with your expertise in applying molecular biology and NGS expertise to the discovery of curing rare diseases using genome engineering.

This is an exciting opportunity to join the Translational Genomics Department within our Global Discovery Sciences function, where we apply cutting edge NGS/transcriptomic technologies, precise genome editing in vitro and in vivo functional genomics model systems and cell therapy expertise to the discovery and development of novel therapies.

What you will do:
In this role you work collaboratively with scientists from our team, different therapy areas and computational biology to apply genomic technologies to further drug discovery. Your responsibility includes to develop, evaluate and implement customized NGS workflows for specific drug discovery projects. As well as plan, design, run, enhance and troubleshoot existing NGS workflows such as bulk RNA-seq (e.g. mRNA-seq, totRNA-seq, ultra low-input) and high-throughput transcriptomics (e.g. 384-well-based methods).

You need to understand and interpret data analyzed by computational biology colleagues and have the ability to communicate it effectively to project partners and stakeholders. Along with this, you will keep records of all lab and technology development work and write technical reports and SOPs. You also have the opportunity to engage in the supervision and mentorship of other junior scientists, ensuring that methods run expertly and accurately, developing and guiding the set-up of new techniques.

Essential for the role:

* Ph.D. degree or MSc with corresponding experience in Molecular Biology, Biotechnology, Biomedicine or in a relevant scientific discipline.
* Hands-on lab-based experience in utilizing advanced molecular biology RNA-sequencing, DNA-sequencing and Epigenetic sequencing techniques.
* This experience will cover all relevant aspects from hypothesis generation, through experimental design and execution, RNA and DNA extraction, sample and library preparation, sequencing (ideally with Illumina or Nanopore), data handling, post-sequencing QC and troubleshooting.
* Background in applying a broad range of wet-lab techniques, such as mammalian cell-culture, high-throughput in-vitro drug testing, qPCR, automated liquid handling is a plus.

The successful candidate is a motivated, creative and innovative scientist with a flexible, collaborative and team-oriented mindset. You like to solve problems in a goal-oriented way and you have the ability to communicate and interact with colleagues across our global AZ functions and fields. Along with this, you have a social personality and will enjoy to contribute to our open, positive, collaborative working climate.

Highly desirable for the role:

* Working with laboratory automation / liquid handling systems, method and technology development and optimization.
* Hands-on experience with Single Cell Transcriptomics or Spatial Transcriptomics.
* Hands-on laboratory experience running NGS platforms (Illumina, Oxford Nanopore etc).
* Sample Tracking by LIMS systems.

Why AstraZeneca?
By sharing and increasing our knowledge we are empowered to be the best we can be and accelerate progress. Thrive in a place where the brightest and most curious minds seamlessly come together in our inclusive environment.

Does this sound like the next challenge for you? Welcome to join us at AstraZeneca!

Please send your application to us as soon as possible, but no later than 18th April, 2022.

For more information about the position please contact Maryam Clausen at Maryam.Clausen@astrazeneca.com.

Additional information
Our Gothenburg site: https://www.astrazeneca.com/our-science/gothenburg.html
Life in Gothenburg: https://www.movetogothenburg.com/
Make a move to Global Gothenburg: https://www.youtube.com/watch?v=c-Iqbb4aw38
About BioPharmaceuticals R&D: https://www.astrazeneca.com/r-d.html